TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells

Kooistra, Klaas; Zhang, Yinghui; Henriquez, Nico V.; Weiß, Bertram; Mumberg, Dominik; Noteborn, Mathieu H. M.

doi:10.1099/vir.0.79790-0

Cited by 43 publications

(26 citation statements)

References 35 publications

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“…TTSuV ORF3 protein also contained NLS/NoLs signals that target it to the nucleolus, but did not contain RCR motifs. In human studies, ORF3 protein function has been associated with apoptosis based on similarities observed with VP3 protein from closely related CAV (Kooistra et al, 2004); such similarities were not found in TTSuV proteins.…”

Section: Discussionmentioning

confidence: 99%

Expression profile and subcellular localization of Torque teno sus virus proteins

Martínez-Guinó

Ballester

Segalés

et al. 2011

Journal of General Virology

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In the present study, the expression, generation and subcellular localization of Torque teno sus virus (TTSuV) proteins were characterized into two genetically distinct TTSuV species (TTSuV1 and TTSuV2). Following transfection of three TTSuV1 and TTSuV2 full-length ORF (ORF1, ORF2 and ORF3) expression constructs into porcine kidney cells, alternative splice variants encoding new TTSuV protein isoforms were identified for the first time. Proteins encoded from ORF1 and ORF3 were localized in the nucleoli of porcine kidney cells and that of ORF2 in the cytoplasm and nucleus excluding the nucleoli. The subcellular localization of the different protein isoforms was not only similar between distinct TTSuV species but also to the ones described in human Torque teno virus (TTV). Results of the present in vitro study were not based on full-length viral clones but suggested that alternative splicing strategy to generate TTSuV protein isoforms probably occurs in vivo. Obtained data provide new information on molecular biology of TTSuV and anelloviruses, which until now has been solely based on results obtained from human TTV.

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Section: Discussionmentioning

confidence: 99%

Expression profile and subcellular localization of Torque teno sus virus proteins

Martínez-Guinó

Ballester

Segalés

et al. 2011

Journal of General Virology

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“…The VP2 and ORF2 of CAV and anellovirus genomes, respectively, encode a protein containing a motif characteristic of protein tyrosine phosphatases (i.e., WX 7 HX 3 CXCX 5 H, where 'X' represents any residue) [60]. In addition, the CAV-VP3 and ORF3 of some anelloviruses encode a protein with comparable apoptotic capacity [33,65].…”

Section: Reassignment Of the Genus Gyrovirus To The Family Anelloviridaementioning

confidence: 99%

Revisiting the taxonomy of the family Circoviridae: establishment of the genus Cyclovirus and removal of the genus Gyrovirus

et al. 2017

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“…In contrast, TAIP, a TTV-derived apoptosis-inducing protein, may block tumorigenesis or induce programmed cell death of carcinoma cells [12]. The ORF2 protein of TTV may also curb tumor development by suppressing the production of inflammatory factors activated by NF-κB [13].…”

Section: Introductionmentioning

confidence: 99%

Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients

Hettmann¹,

Demcsák²,

Bach³

et al. 2016

Intervirology

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Objectives: Because torque teno virus (TTV) has been implicated in tumorigenesis as a cocarcinogen, we studied TTV prevalence in saliva and biopsy samples from head and neck cancer (HNCC) patients, patients with premalignant lesions of oral cancer, and controls. We also wished to determine the TTV genotypes in HNCC patients. Methods: A seminested polymerase chain reaction (PCR) amplifying the N22 region of the TTV genome, as well as direct sequencing of PCR fragments, was used. Results: TTV prevalence was higher in HNCC patients (saliva: 27/71, 38%; tumor biopsy: 22/74, 30%) than in controls (saliva: 8/56, 14%; oral mucosa: 1/19, 5%). TTV prevalence was also high in patients with premalignant lesions of oral carcinoma (saliva: 9/18, 50%; biopsy: 5/21, 24%). By phylogenetic analysis, TTV belonging mostly to genotypes 1 and 2 was found in HNCC patients. In most of the cases, identical TTV strains were present in the biopsy and salivary sample of the same HNCC patient. In addition, the same TTV strain was detected in 2 laryngeal carcinoma biopsies obtained from 2 independent patients. Conclusions: Our data are compatible with the idea that TTV might act as a cocarcinogen in certain cases of HNCC. Alternatively, HNCC may facilitate either TTV replication or TTV entry into the saliva.

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TT virus-derived apoptosis-inducing protein induces apoptosis preferentially in hepatocellular carcinoma-derived cells

Cited by 43 publications

References 35 publications

Expression profile and subcellular localization of Torque teno sus virus proteins

Expression profile and subcellular localization of Torque teno sus virus proteins

Revisiting the taxonomy of the family Circoviridae: establishment of the genus Cyclovirus and removal of the genus Gyrovirus

Detection and Phylogenetic Analysis of Torque Teno Virus in Salivary and Tumor Biopsy Samples from Head and Neck Carcinoma Patients

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