TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

Chen, Bang‐Dang; Chen, Jiayao; Pan, Shuo; Yang, Yi‐Ning; He, Chunhui; Liu, Fen; Ma, Xiang; Gai, Min-Tao; Ma, Yun

doi:10.18632/oncotarget.15851

Cited by 11 publications

(9 citation statements)

References 48 publications

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“…Previous studies described that the mutations in HNF4G gene were not associated with the etiology of diabetes [ 18 , 19 ]. A recent study reported that a polymorphism in HNF4G was associated with hyperuricemia in Chinese Han population [ 20 ]. Recently, Okegawa T et al found that HNF4G expression is significantly elevated in bladder cancer and that HNF4G promotes the growth and invasion of bladder cancer partially by regulating HAS2 [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Expression of HNF4G and its potential functions in lung cancer

Wang

Zhang

et al. 2017

Oncotarget

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The hepatocyte nuclear factor 4 gamma (HNF4G), a member of orphan nuclear receptors, is up-regulated and functions as an oncoprotein in bladder cancer. In the present study, we observed that HNF4G expression was elevated in lung cancer tissues as compared to adjacent normal lung tissues. The expression of HNF4G protein was correlated with the tumor size and the prognosis of patients. Transfection with a small interference RNA (siRNA) targeting HNF4G in two lung cancer cell lines (H358 and H292 cells) significantly inhibited cell proliferation via arresting cells at G1 phase and inducing cell apoptosis. In addition, HNF4G siRNA reduced cell proliferation in a xenograft tumor-bearing model. Moreover, A549 cells, which had relative lower level of HNF4G, were ectopic expressed with HNF4G and treated with an AKT inhibitor (MK-2206). MK-2206 exposure not only attenuated the promoting effects of HNF4G overexpression on cell proliferation and cell cycle progression, but also suppressed the inhibitory effects of HNF4G overexpression on cell apoptosis. These data suggested that AKT signaling pathway was a potential upstream mediator of HNF4G. Collectively, our data indicate that HNF4G exerts as an oncogenic role in lung cancer by promoting cell proliferation and that HNF4G expression is a potential prognosis factor for lung cancer.

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Section: Introductionmentioning

confidence: 99%

Expression of HNF4G and its potential functions in lung cancer

Wang

Zhang

et al. 2017

Oncotarget

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“…HNF4G is a member of the orphan nuclear receptor superfamily (24). In the Chinese Han population, HNF4G polymorphisms are associated with ventilatory disease (25). Wang et al (26) demonstrated that HNF4G acts as an oncogene and can promote the growth and metastasis of lung cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients

Wang¹,

Lu²,

Liu³

et al. 2022

Ann Transl Med

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Background: Isocitrate dehydrogenase 1 (IDH1) mutation status is related to the prognosis and immune microenvironment of glioma. Long non-coding ribonucleic acids (lncRNAs) interact with microRNAs (miRNAs), and play roles in the competitive endogenous RNA (ceRNA) network and tumor progression.Methods: Data on low-grade glioma (LGG) IDH1 mutation was acquired from The Cancer Genome Atlas (TCGA). An empirical analysis of differential gene expression was conducted to identify differentially expressed mRNAs (DEmRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed lncRNAs (DElncRNAs). Survival-associated genes were identified by a univariate Cox regression analysis.An enrichment analysis was conducted to explore the gene ontology and pathways of the DEmRNAs.Results: Eighty-eight DEIDH1mRNAs, 88 DEIDH1lncRNAs, and 6 DEIDH1miRNAs were identified to construct a ceRNA network of LGG patients. Validated by Chinese Glioma Genome Atlas and our LGG patients of gene expression and survival, and the colorectal neoplasia differentially expressed (CRNDE), HOXA transcript antisense RNA, myeloid-specific 1 (HOTAIRM1)/miRNA-206a/hepatocyte nuclear factor 4 (HNF4G) axis was determined. Conclusions:We established a ceRNA network by integrating the different IDH1 mutation statuses of LGG patients, and identified HNF4G, CRNDE, and HOTAIRM1 as genes related to the prognosis of and immune infiltration in LGG patients. Our findings suggest that these genes may be targets for LGG treatment, especially for patients with the wild-type IDH1 gene variants.

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“…Although we have adjusted these factors in our multivariate model, it is still possible that some underlying confounders have been missed. Some previous similar studies have included blood pressure measures as covariates in the multivariate model 10 , 11 , however, we did not collect these measures, so they were not adjusted in our model. This might introduce some confounding effects on our results.…”

Section: Discussionmentioning

confidence: 99%

Genetic association and functional analysis of rs7903456 in FAM35A gene and hyperuricemia: a population based study

Yan

Sun

Zhao

et al. 2018

Sci Rep

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Recent studies have identified SNP rs7903456 of FAM35A to be associated with gout. Because of the close connections between hyperuricemia and gout, we hypothesized that the effect of rs7903456 on gout might be mediated by hyperuricemia or its related quantitative trait, uric acid level. We investigated the association between 31 SNPs of FAM35A, including rs7903456, and hyperuricemia based on 2,773 hyperuricemia patients and controls. We fitted a simple model for each of these 31 SNPs to screen the candidate SNP for further analyses. Moreover, we selected potential confounders and fitted a multivariate model to investigate the adjusted effects of the targeted SNPs. Both disease status of hyperuricemia and blood uric acid level were considered as the main phenotype. We have identified rs7903456 to be associated with hyperuricemia and uric acid level. The significant signal was identified between rs7903456 and uric acid level after adjusted by several potential confounders. Our findings showed that the T allele of rs7903456 could increase the uric acid level by ~10 mmol/L on average after adjusting several biochemical and clinical variables. Our findings indicated that the previously identified effects of rs7903456 on gout might partly be mediated by its effect on uric acid levels.

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TT genotype of rs2941484 in the human HNF4G gene is associated with hyperuricemia in Chinese Han men

Cited by 11 publications

References 48 publications

Expression of HNF4G and its potential functions in lung cancer

Expression of HNF4G and its potential functions in lung cancer

Construction of ceRNA networks with different types of IDH1 mutation status in low-grade glioma patients

Genetic association and functional analysis of rs7903456 in FAM35A gene and hyperuricemia: a population based study

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