Tsukushi controls the hair cycle by regulating TGF-β1 signaling

Niimori, Daisuke; Kawano, Rie; Felemban, Athary; Niimori-Kita, Kanako; Tanaka, Hideaki; Ihn, Hironobu; Ohta, Kunimasa

doi:10.1016/j.ydbio.2012.08.030

Cited by 42 publications

(50 citation statements)

References 34 publications

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“…Furthermore, using the synchronised hair cycle mouse model, we demonstrate that direct injection of decorin accelerates hair anagen growth rates and increases follicle length and hair size, indicating early anagen‐accelerating and late anagen‐extending activities. Taken together, the close spatiotemporal association of decorin expression and HF morphogenesis strongly supports a role for follicle‐derived decorin in hair cycling, consistent with the previous findings demonstrating that Tsukushi, another SLRP, is involved in HF cyclic transitions .…”

Section: Discussionsupporting

confidence: 89%

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

Jing

et al. 2014

Experimental Dermatology

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Decorin is a prototypical member of the small leucine-rich proteoglycan (SLRP) family, which is involved in numerous biological processes. The role of decorin, as a representative SLRP, in hair follicle morphogenesis has not been elucidated. We present our initial findings on decorin expression patterns during induced murine hair follicle (HF) cycles. It was found that decorin expression is exclusively restricted to the epidermis, outer root sheath and sebaceous glands during the anagen phase, which correlates with the upregulation of decorin mRNA and protein expression in depilated murine dorsal skin. Furthermore, we used a functional approach to investigate the effects of recombinant human decorin (rhDecorin) via cutaneous injection into HFs at various murine hair cycle stages. The local injection of rhDecorin (100 μg/ml) into the hypodermis of depilated C57BL/6 mice at anagen delayed catagen progression. In contrast, rhDecorin injection during the telogen phase caused the premature onset of anagen, as demonstrated by the assessment of the following parameters: (i) hair shaft length, (ii) follicular bulbar diameter, (iii) hair follicle cycling score and (iv) follicular phase percentage. Taken together, our results suggest that decorin may modulate follicular cycling and morphogenesis. In addition, this study also provides insight into the molecular control mechanisms governing hair follicular epithelial-mesenchymal interactions.

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Section: Discussionsupporting

confidence: 89%

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

Jing

et al. 2014

Experimental Dermatology

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“…We also reported that TSK controls cell differentiation during the hair cycle by regulating TGF-β1 (Niimori et al 2012). Because follicular stem cells not only supply hair follicles, sebaceous glands, and epidermis, but also regenerate tissue during wound healing (Cotsarelis 2006), we anticipated that TSK could be involved in wound healing.…”

Section: Introductionmentioning

confidence: 97%

Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors

Niimori

Kawano

Niimori-Kita

et al. 2014

Journal of Cell Communication and Signaling

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During the wound-healing process, macrophages, fibroblasts, and myofibroblasts play a leading role in shifting from the inflammation phase to the proliferation phase, although little is known about the cell differentiation and molecular control mechanisms underlying these processes. Previously, we reported that Tsukushi (TSK), a member of the small leucine-rich repeat proteoglycan family, functions as a key extracellular coordinator of multiple signalling networks. In this study, we investigated the contribution of TSK to wound healing. Analysis of wound tissue in heterozygous TSK-lacZ knock-in mice revealed a pattern of sequential TSK expression from macrophages to myofibroblasts. Quantitative PCR and in vitro cell induction experiments showed that TSK controls macrophage function and myofibroblast differentiation by inhibiting TGF-β1 secreted from macrophages. Our results suggest TSK facilitates wound healing by maintaining inflammatory cell quiescence.

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“…SOX9 is essential for maintaining the adult HFSCs 33. SOX-9 was reported to function as an enhancer of Activin/TGFbeta signaling which inhibits the activation of HFSCs 34. Thus we speculate that HFSCs may provide sebaceous gland and epithelial cell resources for the SNs.…”

Section: Discussionmentioning

confidence: 84%

Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms

Qiu

Lei

et al. 2014

Int. J. Med. Sci.

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Sebaceous glands (SGs) undergo cyclic renewal independent of hair follicle stem cells (HFSCs) activation while HFSCs have the potential to differentiate into sebaceous gland cells, hair follicle and epidermal keratinocytes. Abnormalities of sebaceous gland progenitor cells contribute to the development of sebaceous neoplasms, but little is known about the role of HFSCs during sebaceous neoplasm development. Here, using dimethylbenzanthracene (DMBA) plus 12-o-tetradecanoyl phorbol-13-acetate (TPA) treatment developing sebaceous neoplasms (SNs) were identified with H&E and Oil red O staining. And then the molecular expression and activation of HFSCs and was characterized by immunostaining. Wnt10b/β-catenin signaling molecular which is important for activation of HFSCs were detected by immunostaining. We found hair follicle and epidermal cell markers were expressed in sebaceous neoplasms. Furthermore, SOX-9 and CD34-positive HFSCs were located in the basal layer of sebaceous lobules within the sebaceous neoplasms. Many appear to be in an active state. Finally, Wnt10b/β-catenin signaling was activated within the basal cells of sebaceous lobules in the sebaceous neoplasms. Collectively, our findings suggest that the abnormal activation of both HFSCs and Wnt10b/β-catenin signaling involves in the development of sebaceous neoplasms.

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Tsukushi controls the hair cycle by regulating TGF-β1 signaling

Cited by 42 publications

References 34 publications

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

Expression of decorin throughout the murine hair follicle cycle: hair cycle dependence and anagen phase prolongation

Tsukushi is involved in the wound healing by regulating the expression of cytokines and growth factors

Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms

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