TSST-1 protein exerts indirect effect on platelet activation and apoptosis

Guo, Min; Yi, Tiantian; Wang, Qian; Wang, Daqing; Feng, Ping; Dai, Kesheng; He, Chufeng

doi:10.1080/09537104.2022.2026907

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Interactions Of Secreted Bacterial Products With Platelets1

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2023

2024

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Cited by 2 publications

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“…SSL5 has been shown to activate platelets by binding to GPIba and GPVI (135). S. aureus toxic shock syndrome toxin-1 (TSST-1) mediates platelet activation and apoptosis, although the mechanism of TSST-1-mediated platelet activation is unknown (136). Porphyromonas gingivalis secretes gingipains that can mimic thrombin and activate platelets by cleaving proteaseactivated receptors (PAR) (137)(138)(139).…”

Section: Interactions Of Secreted Bacterial Products With Plateletsmentioning

confidence: 99%

Sepsis – it is all about the platelets

Cox

2023

Front. Immunol.

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Sepsis is accompanied by thrombocytopenia and the severity of the thrombocytopenia is associated with mortality. This thrombocytopenia is characteristic of disseminated intravascular coagulation (DIC), the sepsis-associated coagulopathy. Many of the pathogens, both bacterial and viral, that cause sepsis also directly activate platelets, which suggests that pathogen-induced platelet activation leads to systemic thrombosis and drives the multi-organ failure of DIC. In this paper we review the mechanisms of platelet activation by pathogens and the evidence for a role for anti-platelet agents in the management of sepsis.

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