TSPO ligand PK11195 and MAPK inhibitor UO126 modulate TSPO expression in melanoma cells

Gyrylova, S N; Рукша, Т. Г.; Komina, A. V.

doi:10.1134/s1990519x13030073

Cited by 2 publications

(5 citation statements)

References 10 publications

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“…Gene NLRC4 is an important regulator of key inflammatory signaling pathways in macrophages, and published studies have demonstrated that it plays a critical role in suppressing tumor growth in cutaneous melanoma . Gene TPSO has been found to be involved in the appearance of skin melanoma due to modified functional activities caused by mutagenic activation of MAPK signaling cascade and has different expression levels between skin melanoma cells and normal melanocytes …”

Section: Discussionmentioning

confidence: 99%

“…47 Gene TPSO has been found to be involved in the appearance of skin melanoma due to modified functional activities caused by mutagenic activation of MAPK signaling cascade and has different expression levels between skin melanoma cells and normal melanocytes. 48 Analysis is also conducted using the alternatives. The summary comparison results are shown in Table S21 (see Supporting Information), and detailed estimation results using the alternatives are available from the authors.…”

Section: Skcm Datamentioning

confidence: 99%

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Robust semiparametric gene‐environment interaction analysis using sparse boosting

2019

Statistics in Medicine

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For the pathogenesis of complex diseases, gene‐environment (G‐E) interactions have been shown to have important implications. G‐E interaction analysis can be challenging with the need to jointly analyze a large number of main effects and interactions and to respect the “main effects, interactions” hierarchical constraint. Extensive methodological developments on G‐E interaction analysis have been conducted in recent literature. Despite considerable successes, most of the existing studies are still limited as they cannot accommodate long‐tailed distributions/data contamination, make the restricted assumption of linear effects, and cannot effectively accommodate missingness in E variables. To directly tackle these problems, a semiparametric model is assumed to accommodate nonlinear effects, and the Huber loss function and Qn estimator are adopted to accommodate long‐tailed distributions/data contamination. A regression‐based multiple imputation approach is developed to accommodate missingness in E variables. For model estimation and selection of relevant variables, we adopt an effective sparse boosting approach. The proposed approach is practically well motivated, has intuitive formulations, and can be effectively realized. In extensive simulations, it significantly outperforms multiple direct competitors. The analysis of The Cancer Genome Atlas data on stomach adenocarcinoma and cutaneous melanoma shows that the proposed approach makes sensible discoveries with satisfactory prediction and stability.

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Section: Discussionmentioning

confidence: 99%

Section: Skcm Datamentioning

confidence: 99%

Robust semiparametric gene‐environment interaction analysis using sparse boosting

2019

Statistics in Medicine

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“… 77 A study showed that there was an increased level of TSPO protein in differentiated cells (melanoma) compared to normal cells. 6 , 77 Ruksha et al investigated the role of the protein in melanoma pathogenesis in skin biopsies of patients. A previous study found that TSPO levels correlated to increased tumor invasion levels using immunohistochemistry and real-time PCR.…”

Section: Melanomamentioning

confidence: 99%

“…Furthermore, the signaling cascade was often activated by mutations in the B-raf protooncogene gene, leading to the activation of cell proliferation or NRAS. 76,77 The MAPK signaling pathway played an important role in transporting extracellular signals, including hormones and key regulatory proteins to the cell nucleus, enabling the expression of genes for cell proliferation and differentiation. 76 Mutagenic activation of MAPK signaling was a main event underlying tumor progression, and its signaling was known to be triggered by protein kinase C, which modulated the A c c e p t e d M a n u s c r i p t expression of TSPO.…”

Section: Melanomamentioning

confidence: 99%

“…76 Mutagenic activation of MAPK signaling was a main event underlying tumor progression, and its signaling was known to be triggered by protein kinase C, which modulated the A c c e p t e d M a n u s c r i p t expression of TSPO. 77 A study showed that there was an increased level of TSPO protein in differentiated cells (melanoma) compared to normal cells. 6,77 Ruksha et al investigated the role of the protein in melanoma pathogenesis in skin biopsies of patients.…”

Section: Melanomamentioning

confidence: 99%

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Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers

Wongso,

Kurniawan,

Setiadi

et al. 2023

Adv Pharm Bull

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Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified as the peripheral benzodiazepine receptor (PBR). TSPO involves in a broad number of biochemical events, such as steroidogenesis, mitochondrial cholesterol transport, cell survival and death, cell proliferation, and carcinogenesis. Several investigations have reported the roles of TSPO in various types of cancers, including colorectal cancer, brain cancer, melanoma, breast cancer, prostate cancer, and lung cancer. It was found that TSPO is upregulated in cancer cells, and it appears that its expression is parallel with an aggressive phenotype and/or poor prognosis. As a consequence, there is great potential for developing diagnostic and prognostic tools targeting the TSPO. In this regard, several radioligands targeting the TSPO have been identified, and some of the candidates have advanced to clinical trials. In recent years, image-guided surgery using hybrid probes bearing radioactive and fluorescence molecules has demonstrated promising outcomes in animal and human studies, and thus might serve as a valuable surgical navigator during cancer surgery. In general, current hybrid probes are built from various molecular platforms, including small molecules, nanoparticles, and antibodies. Although several TSPO-targeted imaging probes have been developed, their development for image-guided surgery of cancers is scarce. This review highlights recent findings of the involvement of TSPO in carcinogenesis, and provides a new perspective on the potential application of TSPO-targeted hybrid probes for image-guided surgery.

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TSPO ligand PK11195 and MAPK inhibitor UO126 modulate TSPO expression in melanoma cells

Cited by 2 publications

References 10 publications

Robust semiparametric gene‐environment interaction analysis using sparse boosting

Robust semiparametric gene‐environment interaction analysis using sparse boosting

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers

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