TSPAN8
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myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer
Guangjian Fan,
Bo Yu,
Lei Tang
et al.
Abstract:Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor microenvironment that promote cancer progression and relapse. However, the heterogeneity and regulatory roles of CAFs underlying chemoresistance remain largely unclear. Here, we performed a single-cell analysis using high-dimensional flow cytometry analysis and identified a distinct senescence-like tetraspanin-8 (TSPAN8)
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myofibroblastic CAF (myCAF) subset, which is correlated with therapeutic resistance and p… Show more
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