TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease

Duan, Honghong; Jiang, Zhengrong; Chen, Lijun; Bai, Xuefeng; Cai, Huiyao; Yang, Xinna; Huang, Huibin

doi:10.1016/j.intimp.2023.110873

Cited by 4 publications

(2 citation statements)

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“…Further research by Faust shed light on the aforementioned pathogenic mechanism, proposed a model for the physiological and pathological activation of TSHR, and suggested the potential extension of this mechanism to other G protein-coupled receptors with large ECDs. [ 53 ] Duan et al [ 54 ] designed a novel therapy using chimeric antigen receptor T cells. These cells demonstrate the ability to recognize and effectively eliminate B lymphocytes producing TRAb both in vitro and in vivo, offering a promising and innovative immunotherapy for GD.…”

Section: Discussionmentioning

confidence: 99%

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Global research landscape and emerging trends in Graves’ disease: A bibliometric analysis

Yang,

Li,

Zhou

et al. 2024

Medicine

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Background: Graves’ disease is a prevalent thyroid disorder and is the primary cause of hyperthyroidism. Significant progress has been made in understanding the epidemiology, pathogenesis, diagnosis, treatment, and prognosis of this disease. However, bibliometric analyses on Graves’ disease are lacking. We aimed to comprehensively summarize the research, progression, and focal points of Graves’ disease through data mining and integrated analysis of the existing literature. Methods: We retrieved relevant literature on Graves’ disease from 2003 to 2023 from the Web of Science database. We performed bibliometric analysis using CiteSpace and the R package Bibliometrix. Results: We identified 10,901 publications from 132 countries, with a steady rise in the number of publications over the past 5 years. The US leads in publication volume, with the University of California System being the primary contributing institution. The journal Thyroid had the highest publication output, while the Journal of Clinical Endocrinology and Metabolism was the most frequently cited. These publications involved 2305 authors, with Antonelli Alessandro and Smith Terry being the most prolific. The most frequently cited articles were the “2016 American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis” and the “Thyroid Association/European Group on Graves’ orbitopathy guidelines for the management of Graves’ orbitopathy.” Analysis of the bursts of cited references, keywords, and their clustering revealed that research on Graves’ disease predominantly centers on clinical management, thyroid-stimulating hormone receptors, thyroid hormones, autoimmunity and inflammation, Graves’ ophthalmopathy, thyroid nodules, and thyroid cancer. Conclusion: This is the first comprehensive bibliometric study to summarize progress and trends in Graves’ disease research. These results highlight recent research hotspots and promising directions, thereby providing a valuable reference for other scholars.

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Section: Discussionmentioning

confidence: 99%

“…These cells demonstrate the ability to recognize and effectively eliminate B lymphocytes producing TRAb both in vitro and in vivo, offering a promising and innovative immunotherapy for GD. [ 54 ]…”

Section: Discussionmentioning

confidence: 99%