TSHR-Ab Elisa Kit: A Novel Diagnostic Kit for Hashimoto’s and Graves’ Disease Patients

Abstract

Background: one of the global public health problem is Thyroid gland disease. More studies are still required to investigate novel markers to specify the prognosis and recovery of the thyroid gland after both internal and external radiation exposure. Methodology: ELISA was used to quantitatively identify the serum level of TSHR-Ab in human blood specimens of Hashimoto’s and Graves’ disease and normal healthy controls. Results: Increased levels of TSHR-Ab (P<0.01) were observed in Graves' disease patients in comparison to the normal healthy controls, it raising significantly (P < 0.01) after one year of curing with anti-thyroid drugs. In contrast, low levels of TSHR-Ab were observed in Hashimoto’s disease cases, and it decreased significantly (P < 0.01) after treatment. Conclusion: serum TSHR-Ab levels in hyperthyroidism and Hypothyroidism patients might be an effective diagnostic marker that increases the immunological response of T cell and immune system, and optimize the chance for detection and remission of autoimmune thyroid disorder