TSH stimulates leptin secretion by a direct effect on adipocytes

Menéndez, Carmen; Baldelli, Roberto; Camiña, J. P.; Escudero, Beatriz; Peinó, R.; Diéguez, Carlos; Casanueva, Felipe F.

doi:10.1677/joe.0.1760007

Cited by 142 publications

(106 citation statements)

References 51 publications

(50 reference statements)

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“…According to our results, alterations of TSH seem to effect the leptin levels independent from fT 3 and fT 4 levels in each group. All findings in this study point to a strong relationship between TSH and leptin levels in corroboration of some studies [2,14,18].…”

Section: Discussionsupporting

confidence: 92%

“…It has been suggested that this hypoleptinaemia might be related more to the degree of adiposity than to the levels of thyroid hormones [13]. Serum leptin levels may be unchanged [15,16], elevated [9,14,17,18] or even decreased [10,19] as a result of hypothyroidism. Some studies suggest that the activity of the PTA is related to serum leptin levels in patient with thyroid disease, and raise the interesting possibility of a functional link between these two endocrine axes.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies suggest that the activity of the PTA is related to serum leptin levels in patient with thyroid disease, and raise the interesting possibility of a functional link between these two endocrine axes. Interestingly, a recent study on the direct action of TSH on leptin secretion exerted directly at the adipocyte level in human tissue, adds a new dimension to the complex relationship between the two points of the system [18]. The TSH-mediated leptin release may be of interest when trying to understand the leptin pulsation in plasma.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, Mantzoros et al have shown in a systematically and mathematically validated analysis that TSH and leptin exhibit coordinated pulsatility [2]. Menendez et al have shown in their recent study that TSH significantly stimulates leptin secretion by human adipose tissue in vitro, suggesting a new mechanism in the interrelationship between the adipose organ and the thyroid axis [18].…”

Section: Discussionmentioning

confidence: 99%

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TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

et al. 2005

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Abstract. Leptin is considered to play a role in maintenance of energy balance and body weight by neuroendocrine mechanisms. The physiological mechanisms for thyroid hormone-induced alteration in serum leptin are not well known. In the present study, the relationship between thyroid hormones and leptin levels was investigated in patients with overt hypothyroidism and hyperthyroidism before and after successful treatment. Leptin levels were determined by radioimmunoassay and body mass index (BMI) was calculated for each subject. Serum leptin levels of 26 hypothyroid and 22 hyperthyroid patients were compared with those of 20 healthy volunteers who comprised the controls. Serum leptin levels of hypothyroid patients (28.4 ± 4.1 ng/ml) were found to be significantly higher than the controls (19.1 ± 3.2 ng/ml) (p<0.01), whereas hyperthyroid patients had lower levels (10.7 ± 1.2 ng/ml) (p<0.01). In hypothyroid patients, serum leptin levels were decreased significantly to 20.6 ± 2.1 ng/ml with thyroxin treatment (p<0.05). However, in hyperthyroid group, serum leptin levels were increased to 12.4 ± 2.2 ng/ml by treatment (p>0.05). BMI was not changed with the treatment in either group. The serum leptin levels were correlated with BMI and thyrotropin (TSH) in both hypothyroid and hyperthyroid patients. Serum leptin levels are affected in thyroid disorders and the correlation of leptin with TSH is independent of thyroid hormones.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

et al. 2005

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“…21,22 In the post-neonatal period and in children, an important lipolytic effect of TSH on adipose tissue has been described, rapidly declining with increasing age. 15 Other studies have shown that TSH has a role in the regulation of several adipokines synthetized in mature adipocytes 23,24,25 and in the induction of preadipocyte proliferation and differentiation. 26 To our knowledge, this is the first study addressing the expression of TSHR and TRa1 in adipose tissue obtained from obese patients, and evaluating the effect of weight loss on these receptors.…”

Section: Discussionmentioning

confidence: 99%

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

et al. 2009

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Objective: Increased thyroid-stimulating hormone (TSH) and FT 3 levels are often found in clinically euthyroid obese individuals. Information on thyroid gene expression in human adipose tissue is scarce. The objective of this study was to measure the expression of the TSH receptor (TSHR) and the thyroid hormone receptor (TRa1) genes in subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in obese individuals and to test the effect of weight loss on these genes. Study Design and Participants: This study is a prospective study involving 107 obese (body mass index (BMI) ¼ 46±8 kg m À2 , 52 with type 2 diabetes or impaired glucose tolerance) and 12 lean nondiabetic participants. A total of 27 obese patients were restudied 1 year after gastric bypass surgery. Total RNA was extracted from SAT and VAT obtained at baseline from all participants, and from SAT in obese patients post surgery. Results: Circulating TSH and FT 3 levels were 170 and 36%, respectively, higher in obese patients than in controls. In SAT, TSHR and TRa1 were reduced in the obese by 67 and 33%, respectively, regardless of glucose tolerance. A similar trend was found in VAT. Post surgery, a BMI decrease of 33% was associated with a decrease in TSH and FT 3 levels and with a 150 and 70% increase in SAT of TSHR and TRa1, respectively. Conclusion: In both subcutaneous and visceral fat, the thyroid gene expression (especially TSHR) is reduced in obesity. The reversal of these changes with major weight loss and the reciprocal changes in plasma TSH and FT 3 levels suggest a role for adipocytes in the regulation of TSH and thyroid hormones.

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Paradoxical Effects of Partial Leptin Deficiency on Bone in Growing Female Mice

Philbrick

Turner

Branscum

et al. 2015

The Anatomical Record

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Morbidly obese, leptin-deficient ob/ob mice display low bone mass, mild osteoclast-rich osteopetrosis, and increased bone marrow adiposity. While partial leptin deficiency results in increased weight, the skeletal manifestations of partial leptin deficiency are less well defined. We therefore analyzed femora and lumbar vertebrae in growing (7-week-old) female C57BL/6 wildtype (WT) mice, partial leptin-deficient ob/+ mice, and leptin-deficient ob/ob mice. The bones were evaluated by dual energy absorptiometry, microcomputed tomography and histomorphometry. As expected, ob/+ mice were heavier, had more white adipose tissue, and lower serum leptin than WT mice, but were lighter and had less white adipose tissue than ob/ob mice. With a few exceptions, cancellous bone architecture, cell (osteoblast, osteoclast, and adipocyte), and dynamic measurements did not differ between WT and ob/+ mice. In contrast, compared to WT and ob/+ mice, ob/ob mice had lower cancellous bone volume fraction and higher bone marrow adiposity in the femur metaphysis, and higher cancellous bone volume fraction in lumbar vertebra. Paradoxically, ob/+ mice had greater femoral bone volume than either WT or ob/ob mice. There was a positive correlation between body weight and femur volume in all three genotypes. However, the positive effect of weight on bone occurred with lower body weight in leptin-producing mice. The paradoxical differences in bone size among WT, ob/+, and ob/ob mice may be explained if leptin, in addition to stimulating bone growth and cancellous bone turnover, acts to lower the set-point at which increased body weight leads to a commensurate increase in bone size.

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TSH stimulates leptin secretion by a direct effect on adipocytes

Cited by 142 publications

References 51 publications

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

TSH Influences Serum Leptin Levels Independent of Thyroid Hormones in Hypothyroid and Hyperthyroid Patients

Expression of thyrotropin and thyroid hormone receptors in adipose tissue of patients with morbid obesity and/or type 2 diabetes: effects of weight loss

Paradoxical Effects of Partial Leptin Deficiency on Bone in Growing Female Mice

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