TSH concentration within the normal range is associated with cognitive function and ADHD symptoms in healthy preschoolers

Álvarez-Pedrerol, Mar; Ribas-Fitó, Núria; Torrent, Maties; Júlvez, Jordi; Ferrer, Carlos; Sunyer, Jordi

doi:10.1111/j.1365-2265.2007.02871.x

Cited by 56 publications

(52 citation statements)

References 55 publications

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“…b Log-transformed TSH levels. perceptual performance MSCA outcomes (44), consistent with the present findings. By contrast, other authors reported that higher newborn T 4 was unexpectedly associated with lower scores on the visual recognition memory test at the age of 6 months but not with scores for verbal abilities, intelligence or visual motor abilities at the age of 3 years (45).…”

Section: Discussionsupporting

confidence: 82%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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Objective: An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development. Design: We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in [2000][2001][2002]. Methods: TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae. Results: Mean newborn TSH was 3.55 mU/l (rangeZ0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)Z2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoring !P20 on span memory (ORZ5.73), whereas children with TSH in the second quartile (2.05-2.95 mU/l) were at lower risk of scoring !P20 on the verbal scale (ORZ0.24). Neonatal TSH status was also associated with general cognitive and executive function outcomes when controlling for prenatal exposure to OCs or placental TEXB. Conclusions: Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.

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Section: Discussionsupporting

confidence: 82%

Newborn TSH concentration and its association with cognitive development in healthy boys

Freire

Ramos²,

Amaya³

et al. 2010

European Journal of Endocrinology

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“…The long-term clinical consequences of compensated hyperthyrotropinemia beginning in early life have not been sufficiently researched, and it is biologically plausible that isolated hyperthyrotropinemia causes minimal abnormalities, with very subtle manifestations. In pediatric populations, Á varez-Pedrerol et al (22) as well as Freire et al (23) found an inverse association between TSH levels (within the normal range) at birth and later neurocognitive functions in childhood (higher TSH levels have lower scores in subsequent cognitive testing methods). In consonance with our results, Á varez-Pedrerol et al argued that TSH concentrations inversely reflect tri-iodothyronine (T 3 ) and T 4 sensed by the pituitary gland.…”

Section: Discussionmentioning

confidence: 99%

Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status

Cuestas

Gaido

Capra

2015

European Journal of Endocrinology

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Objective: Transient neonatal hyperthyrotropinemia (TNH) is defined as a neonatal abnormality of thyroid function, which reverts to normal at re-examination after 2 weeks of life. The thyroid function of these infants has not been sufficiently studied in terms of the risk of developing persistent hyperthyrotropinemia (PH) in later childhood and its impact on growth and development. Design: A prospective cohort study included all babies born in our hospital between 2001 and 2006 and screened for hypothyroidism, whose thyroid function was re-examined 6 years later. Exclusion criteria included the following conditions: preterm birth, birth weight !2500 g, Down's syndrome, descendants of mothers with immune thyroid disease, congenital malformations, cardiac, renal, hepatic, and metabolic diseases, and steroid or dopamine medication. The variables included are TSH and thyroxine at neonatal screening and 6 years later. Main outcomes are the risk of developing PH in childhood, linear growth, and development using Parents' Evaluation of Developmental Status (PEDS). Results: Out of 5040 normal-term newborns, 301 (6.0%, 95% CI 5.3-6.6%) have TSH R10 mU/l (TNH). Six years later, we re-examined 65 randomly selected children with TNH and 185 controls. In the TNH cohort, we found six out of 65 children (9.2%, 95% CI 1.4-17.0%) with PH (TSH R6.4 mU/l), and three out of 185 (1.6%, 95% CI 0.3-4.7%) among controls, relative risk 5.7 (95% CI 1.5-22.1), PZ0.0114. TSH and developmental delay were found to be significantly higher in the TNH cohort (4.7G1.3 mU/l vs 2.1G0.5 mU/l, P!0.0001 and 15/65 (23%, 95% CI 12-34.1) vs 21/185 (11.3%, 95% CI 6.5-16.2) PZ0.0348). Conclusions: Newborns with TNH have a higher risk of developing PH in childhood, with repercussion on developmental status.

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“…Nevertheless, some studies suggested that subtle changes in thyroid hormone homeostasis may affect the development of the central nervous system, as growth and development in the fetus and during childhood is highly dependent on normal levels of thyroid hormones (Dussault and Ruel, 1987). One study of preschool children found that TSH levels in the upper quartile of the normal range were related to impairment of cognitive function and attention behavior (Alvarez-Pedrerol et al, 2007b). Moreover, thyroid hormone disruption has been proposed as a potential mechanism of action for the neurodevelopment effects of certain OCs (Porterfield, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Thyroid hormones are involved in neuronal migration and proliferation (Lavado-Autric et al, 2003) and in synaptogenesis and myelinization (Rice and Barone, 2000). Slight differences in the concentration of thyroid hormones during pregnancy or after delivery may lead to impaired neurocognitive development in children (Pop et al, 2003;Alvarez-Pedrerol et al, 2007b).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

López-Espinosa

Vizcaino

Murcia

et al. 2009

J Expo Sci Environ Epidemiol

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It has been suggested that prenatal exposure to some organochlorine compounds (OCs) may adversely affect thyroid function and may, therefore, impair neurodevelopment. The main aim of this study was to examine the relationship of cord serum levels of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (4,4 0 -DDT), 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene (4,4 0 -DDE), b-hexachlorocyclohexane (b-HCH), hexachlorobenzene (HCB), four individual polychlorobiphenyl (PCB) congeners (118, 138, 153, and 180), and their sum, with neonatal thyroid stimulating hormone (TSH) levels in blood samples in a mother-infant cohort in Valencia, Spain. This study included 453 infants born between 2004 and 2006. We measured OC concentrations in umbilical cord serum and TSH in blood of newborns shortly after birth. Associations between neonatal TSH levels and prenatal OC exposure adjusted for covariates were assessed using multivariate linear regression analyses. Neonatal TSH levels tended to be higher in newborns with b-HCH levels in umbilical cord above 90th percentile (104 ng/g lipid) than in those with levels below the median (34 ng/g lipid), with an adjusted increment in neonatal TSH levels of 21% (95% confidence interval ¼ À3, 51; P ¼ 0.09). No statistically significant association was found between the remaining OCs and TSH at birth. Prenatal exposure to b-HCH may affect neonatal thyroid hormone status and its function in neurological development.

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TSH concentration within the normal range is associated with cognitive function and ADHD symptoms in healthy preschoolers

Cited by 56 publications

References 55 publications

Newborn TSH concentration and its association with cognitive development in healthy boys

Newborn TSH concentration and its association with cognitive development in healthy boys

Transient neonatal hyperthyrotropinemia is a risk factor for developing persistent hyperthyrotropinemia in childhood with repercussion on developmental status

Prenatal exposure to organochlorine compounds and neonatal thyroid stimulating hormone levels

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