TSH and ACTH Secretion and Cyclic Adenosine 3'5' Monophosphate Content following Stimulation with TRH or Lysine Vasopressin in Vitro: Suppression by Thyroxine and Dexamethasone

Rose, James C.; Conklin, P. M.

doi:10.3181/00379727-158-40239

Cited by 13 publications

(3 citation statements)

References 11 publications

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“…Our data also suggest that the Recently some investigators indicated that vasopressin potentiated the ovine CRF-induced ACTH release [5,6]. Rose and Cohlin [22] showed that lysine vasopressin (LVP) increased the release of ACTH and cyclic AMP in experi ments using rat pituitary fragments. On the other hand, Giguere and Labrie [6] reported that an agonistic analog of A VP had no effect on basal cyclic AMP accumulation but potentiated the CRF-induced cyclic AMP accumulation and ACTH release in cultured rat anterior pituitary cells.…”

Section: Discussionsupporting

confidence: 60%

Calmodulin Inhibitors Decrease the CRF- and AVP-Induced ACTH Release in vitro: Interaction of Calcium-Calmodulin and the Cyclic AMP System

Murakami¹,

Hashimoto²,

Ota³

1985

Neuroendocrinology

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The effect of N-(6-aminohexyl)-5-chloro-naphthalene-l-sulfomide (W-7) and trifluoperazine (TFP) was examined on ACTH release from cultured rat anterior pituitary cells and pituitary halves. These drugs significantly inhibited the ACTH release induced by synthetic ovine corticotropin-releasing factor (CRF) in a dose-related manner. In pituitary halves, arginine vasopressin (AVP) at 10 and 100 ng/ml showed almost the same ACTH-releasing activity as CRF at the same concentrations. W-7 and TFP inhibited the CRF- and AVP-induced ACTH release from pituitary halves. The cyclic AMP levels in the pituitary halves were significantly increased by CRF, but not AVP. Although W-7 inhibited CRF-in-duced ACTH release, it did not have an effect in cyclic AMP accumulation. These results suggest that CRF exerts ACTH-releasing activity through both the calcium-calmodulin system and cyclic AMP system and that AVP stimulates ACTH release mainly through the calcium-calmodulin system.

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Section: Discussionsupporting

confidence: 60%

Calmodulin Inhibitors Decrease the CRF- and AVP-Induced ACTH Release in vitro: Interaction of Calcium-Calmodulin and the Cyclic AMP System

Murakami¹,

Hashimoto²,

Ota³

1985

Neuroendocrinology

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“…These data pertain to the reported stimulatory effect of TRH on cAMP accumulation in intact anterior pituitary glands (33)(34)(35) and in tumor cells (36) in vitro. DA, on the other hand, inhibits adenylate cyclase activity in the pituitary gland (36)(37)(38).…”

Section: Discussionmentioning

confidence: 57%

Direct Effects of Sex Steroids on Prolactin Release at the Anterior Pituitary Level: Interactions with Dopamine, Thyrotropin-Releasing Hormone, and Isobutylmethylxanthine

et al. 1982

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When present alone for 4 or 8 days, 5 alpha-dihydrotestosterone (DHT) or the pure progestin R5020 (17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione) inhibits spontaneous PRL release by 33--50% in rat anterior pituitary cells in primary culture. This inhibitory effect of DHT and R5020 can only be partially reversed by 17 beta-estradiol (E alpha). DHT and R5020 inhibit spontaneous PRL release in E2-primed cells at ED50 values of 0.5 and 3 nM, respectively. While E2 diminishes by 30--60% the maximal inhibitory effect of dopamine on PRL release and increases by 10-fold the ED50 value of dopamine action, DHT and R5020 can prevent by 30--60% the action of E2 and thus increase the potency of dopamine to inhibit PRL release. The inhibitory action of DHT and R5020 as well as the stimulatory action of E2 on spontaneous PRL release are similarly expressed on TRH- and 3-isobutyl-1-methylxanthine-induced PRL release, thus suggesting that at least part of the highly effective modulatory effects of sex steroids are exerted at a step after cAMP formation.

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“…After 48 h, the primary cell monolayers were washed with F-12 medium without serum and incubated in parallel in F-12 medium without serum with AtT-20/NYU-1 cells. Release of ACTH from adenohypophyseal cells in culture was found to increase 1.4-to 2-fold during a 1-h exposure to 10 nM vasopressin as previously described (24,25) demonstrating that these cells were responsive to a secretagoguie.…”

Section: Introductionmentioning

confidence: 91%

Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production by Mouse Pituitary Tumor Cells in Culture

Gershengorn¹,

Arevalo²,

Geras³

et al. 1980

J. Clin. Invest.

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TSH and ACTH Secretion and Cyclic Adenosine 3'5' Monophosphate Content following Stimulation with TRH or Lysine Vasopressin in Vitro: Suppression by Thyroxine and Dexamethasone

Cited by 13 publications

References 11 publications

Calmodulin Inhibitors Decrease the CRF- and AVP-Induced ACTH Release in vitro: Interaction of Calcium-Calmodulin and the Cyclic AMP System

Calmodulin Inhibitors Decrease the CRF- and AVP-Induced ACTH Release in vitro: Interaction of Calcium-Calmodulin and the Cyclic AMP System

Direct Effects of Sex Steroids on Prolactin Release at the Anterior Pituitary Level: Interactions with Dopamine, Thyrotropin-Releasing Hormone, and Isobutylmethylxanthine

Thyrotropin-releasing Hormone Stimulation of Adrenocorticotropin Production by Mouse Pituitary Tumor Cells in Culture

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