TSG-6 inhibits the NF-κB signaling pathway and promotes the odontogenic differentiation of DPSCs via CD44 in an inflammatory environment
Ying Wang,
Yulang Xie,
Ningning Xue
et al.
Abstract:In pulpitis, dentinal restorative processes are considerably associated with undifferentiated mesenchymal cells in the pulp. This study aimed to investigate strategies to improve the odonto/osteogenic differentiation of dental pulp stem cells (DPSCs) in an inflammatory environment. After pretreatment of DPSCs with 20 ng/mL tumor necrosis factor-induced protein-6 (TSG-6), DPSCs were cultured in an inflammation-inducing solution. Real-time polymerase chain reaction and western blotting were performed to measure … Show more
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