Tryptophan restriction causes long‐term plastic changes in corticofrontal pyramidal neurons

González-Burgos, Ignacio; Angel-Meza, A.R. Del; Barajas-López, G; Feria‐Velasco, Alfredo

doi:10.1016/0736-5748(96)00094-9

Cited by 19 publications

(8 citation statements)

References 30 publications

(4 reference statements)

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“…Here, we found that transient 5‐HT depletion led to a permanent reduction in dendritic complexity of pyramidal neurons in layers III and V of the somatosensory cortex. Interestingly, this effect is similar to that induced by a low‐tryptophan diet (Gonzalez‐Burgos et al ., 1996; Feria‐Velasco et al ., 2002). Indeed, diets that restrict tryptophan intake, the essential amino acid necessary for 5‐HT synthesis, have been found to reduce dendritic arborization and number of dendritic spines of pyramidal neurons in the hippocampus and in layer III of the prefrontal cortex.…”

Section: Discussionsupporting

confidence: 79%

Embryonic depletion of serotonin affects cortical development

Vitalis

Cases

Passemard

et al. 2007

Eur J of Neuroscience

137

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Compelling evidence suggests that serotonin (5-HT) is necessary for the refined organization of the cerebral cortex. Here we sought to analyse the short- and long-term consequences of embryonic 5-HT depletion on the development of the cerebral neocortex of the rat. We focused on the migration and differentiation of the pyramidal (projection) and nonpyramidal (interneuron) neuronal populations. Our paradigm used daily injection of DL-P-chlorophenylalanine (PCPA), a reversible inhibitor of 5-HT synthesis, during the E12-17 stage of embryonic development, when major events in corticogenesis take place. We monitored the 5-HT depletion induced by this treatment and showed that it led to subtle alterations in both the pyramidal and nonpyramidal neuronal populations. We found that E12-17 PCPA treatment altered the maturation of pyramidal neurons of layers III and V of the somatosensory cortex, with these cells displaying reduced dendritic arborization and complexity. These long-lasting alterations were not associated with modification of cortical BDNF levels at postnatal stages. We also showed that PCPA treatment transiently altered the incorporation in the cortical plate of interneurons derived from the caudal ganglionic eminence, and persistently affected the differentiation of a subpopulation expressing calretinin and/or cholecystokinin.

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Section: Discussionsupporting

confidence: 79%

Embryonic depletion of serotonin affects cortical development

Vitalis

Cases

Passemard

et al. 2007

Eur J of Neuroscience

137

View full text Add to dashboard Cite

show abstract

“…It is well known that axons coming from the rostral raphe nuclei provide major serotonergic projections to the forebrain and hippocampus (Azmitia and Segal, 1978;Datiche et al, 1995;Freund et al, 1990;Pérez-Vega et al, 2000). Data from our laboratory show an increment in the number of dendritic spines in the pyramidal cells of the prefontral cerebral cortex in both, the rats fed with a diet restricted in TRY (González-Burgos et al, 1996), and under conditions of selective pharmacological lesion of the dorsal raphe nucleus in rats (Pérez-Vega et al, 2000).…”

Section: Role Of 5-ht In Brain Developmentmentioning

confidence: 64%

“…Side effects to the reduction of 5-HT due to a diminishing of that indolamine producing neurons might be related to disturbances on behavioral manifestations where 5-HT is involved (González-Burgos et al, 1996). This neurotransmitter is directly related to sleep-awake cycles, depressive conditions, anxiety, feeding, pain control and sexual behaviors (Fernstrom, 1981;Tissari and Tikkanem, 1977).…”

Section: Role Of 5-ht In Brain Developmentmentioning

confidence: 99%

Corn feeding during development induces changes in the number of serotonergic neurons in the raphe nuclei

Orozco‐Suárez

Angel²,

Beas‐Zárate³

et al. 2003

Intl J of Devlp Neuroscience

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Serotonin (5-HT) plays a trophic role during brain development; chronic changes in cerebral concentration of this neurotransmitter during the critical stage of development can produce severe damage in the formation of the neural circuits. For the present work a hypoproteic (HYP) diet based on corn (CORN) meal which is deficient in tryptophan (TRY) was given to rats before and during pregnancy, which continued to the offspring until they reached 60 days of age. An isocaloric but hypoproteic diet containing normal amount of TRY, and normal chow (Ch) Purina were given with the same scheme to two groups of rats considered as controls. 5-HT immunohistochemistry was revealed by avidin-biotin complex (ABC) method to quantify serotonergic nerve cells in the nine raphe nuclei. The number of cells immunoreactive to 5-HT immunoreactive (5-HTir) were quantified by means of stereological analysis. Results demonstrated a significant variation in 5-HT expression in the raphe nuclei. Thus, a significant reduction in the number of 5-HTir cells in the rostral raphe nuclei was seen at all ages studied in the animals fed the corn diet, compared to data obtained from the control groups. This decrease was more evident between the postnatal ages of 30 and 60 days. It is concluded that the variations in the available TRY affect the brain cells producing 5-HT and the innervation of their target areas.

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“…Animals fed with low tryptophan diet [197,198] display cortical pyramidal neurons with decreased dendritic complexity and spine density. Thus, 5-HT may regulate dendritic maturation and spine density through different types of 5-HT receptors that remain to be identified.…”

Section: Serotonin and Dendritic Maturation Of Cortical Neuronsmentioning

confidence: 99%

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

Vitalis¹,

Verney²

2017

Serotonin - A Chemical Messenger Between All Types of Living Cells

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The mammalian cerebral cortex is critical for sensory and motor integrations and, for higher-order cognitive functions. The construction of mammalian cortical circuits involves the coordinated interplay between cellular processes such as proliferation, migration and differentiation of neural and glial cell subtypes followed by accurate connectivity evolving in complexity in primates. Alteration in cortical development may induce the emergence of various pathological traits and behaviours. Among the large array of factors that regulate the assembly of cortical circuits, serotonin (5-HT) plays important role as a developmental signal that impacts on a broad diversity of cellular processes. 5-HT plays distinct roles during specific sensitive periods and is produced from various sources depending on the perinatal stage. Its roles are mediated by more than fourteen 5-HT receptors that are all G-protein coupled receptors except the ionotropic 5-HT type 3A receptor (5-HT 3A ) mediating rapid neuronal activation. Importantly, 5-HT metabolism and signalling are influenced by numerous epigenetic and genetic factors, including nutrition and gut microbiota, perinatal stress, infection and inflammation. In this review, we will recapitulate some evidences showing that dysregulation of 5-HT homeostasis and 5-HT 3A signalling impairs distinct steps of cortical circuit formation leading to the predisposition of the onset of various psychiatric diseases.

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Tryptophan restriction causes long‐term plastic changes in corticofrontal pyramidal neurons

Cited by 19 publications

References 30 publications

Embryonic depletion of serotonin affects cortical development

Embryonic depletion of serotonin affects cortical development

Corn feeding during development induces changes in the number of serotonergic neurons in the raphe nuclei

Sculpting Cerebral Cortex with Serotonin in Rodent and Primate

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