Tryptophan Metabolism in Women Using Steroid Hormones for Ovulation Control

Price, J. M.; Thornton, Madeline J.; Mueller, Lois M.

doi:10.1093/ajcn/20.5.452

Cited by 120 publications

(18 citation statements)

References 12 publications

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“…In contrast with previous reports (24,25), there were not significant differences in plasma CRP between OC users and nonusers. Our observations regarding tryptophan metabolites in OC users vs. nonusers are in accordance with previous studies that showed higher concentrations of these metabolites in OC users (53)(54)(55). Increased metabolite concentrations can be explained by the inductive effect of estrogen on tryptophan 2,3-dioxygenase, the first enzyme in the tryptophan catabolic pathway in the liver (56).…”

Section: Discussionsupporting

confidence: 92%

Metabolite Profile Analysis Reveals Association of Vitamin B-6 with Metabolites Related to One-Carbon Metabolism and Tryptophan Catabolism but Not with Biomarkers of Inflammation in Oral Contraceptive Users and Reveals the Effects of Oral Contraceptives on These Processes,

Rios‐Avila¹,

Coats²,

Chi³

et al. 2015

The Journal of Nutrition

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PLP is associated with biomarkers of one-carbon metabolism and tryptophan catabolism but not with biomarkers of inflammation in OC users. Independent of vitamin B-6 status, OCs have effects on metabolites and ratios of one-carbon metabolism and tryptophan catabolism but not on biomarkers of inflammation. This study was registered at clinicaltrials.gov as NCT01128244. The study from which data for nonusers was derived was registered as NCT00877812.

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Section: Discussionsupporting

confidence: 92%

Metabolite Profile Analysis Reveals Association of Vitamin B-6 with Metabolites Related to One-Carbon Metabolism and Tryptophan Catabolism but Not with Biomarkers of Inflammation in Oral Contraceptive Users and Reveals the Effects of Oral Contraceptives on These Processes,

Rios‐Avila¹,

Coats²,

Chi³

et al. 2015

The Journal of Nutrition

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“…The ratio of the sum of insulin values to that of blood glucose during GTT in Group B was 0.181±0.006 which was significantly lower than 0.203±0.015 in Group C (p<0.01). (Altman and Greengard 1966;Price et al 1967;Rose and Braidman 1971). We produced pyridoxine deficient rats by giving pyridoxine-free food with deoxypyridoxine which inhibits competitively the activity of pyridoxal phosphate.…”

Section: Resultsmentioning

confidence: 99%

The endocrine pancreas in pyridoxine deficient rats.

Toyota

Kai

Kakizaki

et al. 1981

Tohoku J. Exp. Med.

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“…These considerations led to the suggestion that similar derivatives formed from the oestrogen component of the oral contraceptives may be responsible, at least in part, for the abnormal tryptophan metabolism by women using these preparations (Rose, 1966;Price, Thornton & Mueller, 1967;Mason, Ford & Wu, 1969).…”

Section: Discussionmentioning

confidence: 99%

Experimental Vitamin B6 Deficiency and the Effect of Oestrogen-Containing Oral Contraceptives on Tryptophan Metabolism and Vitamin B6 Requirements

et al. 1972

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S U M M A R Y1. A vitamin &-deficient diet was fed to an adult male subject to confirm previously described changes in tryptophan metabolism and urinary 4-pyridoxic acid excretion, and erythrocyte alanine and aspartate aminotransferase activities.2. The results were compared with those obtained in women taking oestrogencontaining oral contraceptives.3. The development of dietary vitamin B, deficiency was indicated by decreased 4-pyridoxic acid excretion, increased urinary concentrations of xanthurenic acid, kynurenine and 3-hydroxykynurenine, an elevated 3-hydroxykynurenine/3-hydroxyanthranilic acid ratio and impaired erythrocyte aminotransferase activities.4. Tryptophan metabolites and 4-pyridoxic acid excretion were determined in thirty-one women when they had been taking an oral contraceptive for 6-36 months. Of these, twenty-six had abnormal tryptophan metabolism, but the 4-pyridoxic acid was decreased in only seven. In six of these seven a raised 3-hydroxykynurenine/3-hydroxyanthranilic acid ratio supported a diagnosis of subclinical vitamin B, deficiency; erythrocyte alanine aminotransferase activity was determined in five of the six, and was decreased in three. 5. Erythrocyte aminotransferases were determined in sixteen women when they had been taking an oral contraceptive for 3-6 months, and in thirty-four women after 6-36 months treatment. Neither group showed any change in alanine aminotransferase activity, but the aspartate aminotransferase was elevated in the group treated for 6 months or longer.The metabolic pathway by which L-tryptophan is converted into nicotinic acid ribonucleotide, and several of the side reactions along the main pathway, involve pyridoxal phosphate dependent enzyme systems (Fig. I), and in consequence a disturbance of tryptophan metabol-

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Tryptophan Metabolism in Women Using Steroid Hormones for Ovulation Control

Cited by 120 publications

References 12 publications

Metabolite Profile Analysis Reveals Association of Vitamin B-6 with Metabolites Related to One-Carbon Metabolism and Tryptophan Catabolism but Not with Biomarkers of Inflammation in Oral Contraceptive Users and Reveals the Effects of Oral Contraceptives on These Processes,

Metabolite Profile Analysis Reveals Association of Vitamin B-6 with Metabolites Related to One-Carbon Metabolism and Tryptophan Catabolism but Not with Biomarkers of Inflammation in Oral Contraceptive Users and Reveals the Effects of Oral Contraceptives on These Processes,

The endocrine pancreas in pyridoxine deficient rats.

Experimental Vitamin B6 Deficiency and the Effect of Oestrogen-Containing Oral Contraceptives on Tryptophan Metabolism and Vitamin B6 Requirements

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