Tryptophan Metabolism in Developmental Origins of Health and Disease (DOHaD)
Sandra Lopes Souza,
Cristiano Mendes Silva,
Dayane Aparecida Gomes
et al.
Abstract:Tryptophan, an essential amino acid in mammals obtained from the diet, is influenced by maternal diet, which impacts early life and development of offspring. This is studied under the Developmental Origins of Diseases and Health (DOHaD) concept, so factors from conception to early childhood affect health and disease susceptibility. Tryptophan is metabolized mainly through two pathways: serotonin (5-HT) and kynurenine. The kynurenine pathway, active in the brain, gut, liver, and placenta, breaks down over 95% o… Show more
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