Tryptophan in the Treatment of Depression

Coppen, Alec; Shaw, DavidM.; Herzberg, Brenda; Maggs, Ronald

doi:10.1016/s0140-6736(67)91894-6

Cited by 269 publications

(63 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tryptophan has been employed widely in many psychiatric syndromes, often with promising results (6,7,13).…”

Section: Methodsmentioning

confidence: 99%

Metabolic Control of Body Temperature in Man

Jw¹,

L²,

Little³

1973

Int Pharmacopsychiatry

View full text Add to dashboard Cite

The Feldberg and Myers (8, 9) hypothesis concerning body temperature regulation asserts that the delicate balance between heat production and heat loss is maintained by the relative activity of serotonin and noradrenalin neurons located in the anterior hypothalamus. This hypothesis is consistent with observations in several species of animals and birds since 1964, but not yet in man. In a therapeutic trial of l-tryptophan in schizophrenia, adequate doses of an MAOI drug and l-tryptophan were administered sequentially to seven human females, with the object of fostering the accumulation of predominantly noradrenalin in the brain by the former and exclusively of serotonin by the latter. Rectal temperatures were measured twice daily. It was found that the MAOI drug alone brought about a fall in body temperature whereas the MAOI drug combined with l-tryptophan caused a rise in the majority of patients.

show abstract

“…Tryptophan has been employed widely in many psychiatric syndromes, often with promising results (6,7,13).…”

Section: Methodsmentioning

confidence: 99%

Metabolic Control of Body Temperature in Man

Jw¹,

L²,

Little³

1973

Int Pharmacopsychiatry

View full text Add to dashboard Cite

show abstract

“…So far, 5-HTP has been used only sporadically, and never in large dosis over a period of several weeks (Kline et al, 1964;Pare and Sandler, 1959;Persson and Roos, 1967). The mother substance /-tryptophan has been so used, but without unequivocal results (Carroll et al, 1970;Coppen et al, 1967). In the light of the controversial findings, something I have already mentioned may be of relevance.…”

Section: -Htp As Antidepressant: the Possible Predictive Value Of Thmentioning

confidence: 99%

Serotonin Metabolism in Depression: Clinical Application of the Probenecid Test1

Praag

Korf²

1974

Int Pharmacopsychiatry

View full text Add to dashboard Cite

The MA hypotheses presume a relationship between disturbances in the central MA metabolism and the occurrence of depressive symptoms. One part of the MA hypotheses is the serotonin hypothesis, in which a relation is presumed between central serotonin deficiency and depression. The arguments in favour of this hypothesis are discussed, and particular attention is paid to data collected with the probenecid technique. The conclusion is, that there are depressions with and without serotonin deficiency and that their differentiation is of importance for proper treatment.

show abstract

“…There is also evidence of low levels of 5-HT in the hindbrains of depressive suicides . and the administration of tryptophan can be used as an effective treatment of depression (Coppen et al, 1967). …”

Section: The 3ietabo1ism Of Tryptophanmentioning

confidence: 99%

Depression Induced by Oral Contraception and the Role of Vitamin B6 in its Management

Leeton¹

1974

Aust N Z J Psychiatry

View full text Add to dashboard Cite

Tryptophan in the Treatment of Depression

Cited by 269 publications

References 21 publications

Metabolic Control of Body Temperature in Man

Metabolic Control of Body Temperature in Man

Serotonin Metabolism in Depression: Clinical Application of the Probenecid Test1

Depression Induced by Oral Contraception and the Role of Vitamin B6 in its Management

Contact Info

Product

Resources

About