Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

Lee, Ji Young; Glynn, Tiffany R.; Moskowitz, Judith T.; Fuchs, Dietmar; Neilands, Torsten B.; Dilworth, Samantha E.; Feaster, Daniel J.; Rodríguez, Allan

doi:10.1007/s13365-020-00937-x

Cited by 5 publications

(2 citation statements)

References 34 publications

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“…Greater depression symptoms in PWH are associated with both lower plasma tryptophan and higher plasma kynurenine/tryptophan ratio (indicating inflammation-associated tryptophan degradation). 47,48 Meanwhile, lower concentration of homovanillic acid (the primary metabolic of dopamine) is associated with increased depression symptoms in PWH. This may be from decreased turnover of phenylalanine (which is a precursor to dopamine) during HIV.…”

Section: Discussionmentioning

confidence: 99%

Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV

Anderson

Bhondoekhan

Curanovic

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Background: People with HIV (PWH) are more likely to experience depression, a highly morbid disease. More evidence is needed to better understand mechanisms of depression in PWH. We evaluated a panel of blood biomarkers in relation to depression symptoms in the Multicenter AIDS Cohort Study (MACS).Setting: Four sites in the United States.Methods: A cross-sectional analysis was performed within the MACS, a prospective study of cisgender men with and without HIV. Depression was assessed with the Center for Epidemiological Studies-Depression Scale, and six blood biomarkers were measured: GlycA, high sensitivity C-reactive protein (CRP), interleukin-6, CCL2, soluble CD14 (sCD14), and soluble CD163 (sCD163). Using univariable and multivariable logistic regression, the biomarkers and other factors were evaluated in relation to significant depression symptoms (SDS) by Center for Epidemiological Studies-Depression score $16.Results: 784 men were analyzed; most of whom (63%) were PWH.PWH were more likely to have SDS (32% vs. 21%). In univariable analysis, higher GlycA, CRP, and sCD163 concentrations were associated with SDS. In multivariable analysis, however, only higher sCD163 concentration was associated with SDS (odds ratio = 2.30, 95% CI = 1.11 to 4.76). This relationship was driven by the PWH group (odds ratio = 2.72, 95% CI = 1.12 to 6.58) and remained significant when controlling for antidepressant use. Lack of college education was also associated with SDS.Conclusions: Higher sCD163, a marker of macrophage activation, was significantly associated with significant depression symptoms in the MACS. Further research on this biomarker and macrophage activation in general is warranted to better understand and treat depression in PWH.

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Section: Discussionmentioning

confidence: 99%

Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV

Anderson

Bhondoekhan

Curanovic

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…The mechanistic importance of tryptophan catabolism is supported by in vitro experimental findings that 3-hydroxyanthranilic acid (a catabolite of tryptophan) decreases the ratio of Th 17 to regulatory T cells in peripheral blood mononuclear cells ( 84 ). Because tryptophan catabolites cross the blood-brain barrier ( 96 ), there is also biological plausibility for observed associations of tryptophan depletion in plasma with cognitive impairment, depressed mood, anhedonia, and impulsivity in PWH ( 85 , 97 , 98 ).…”

Section: This Is Now: Microbiome-gut-brain Axis Alterations Relevant ...mentioning

confidence: 99%

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

et al. 2022

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Objective: Depression, substance use disorders, and other neuropsychiatric comorbidities are common in people with HIV (PWH), but the underlying mechanisms are not sufficiently understood. HIV-induced damage to the gastrointestinal tract potentiates residual immune dysregulation in PWH receiving effective antiretroviral therapy. However, few studies among PWH have examined the relevance of microbiomegut-brain axis: bidirectional crosstalk between the gastrointestinal tract, immune system, and central nervous system. Methods: A narrative review was conducted to integrate findings from 159 articles relevant to psychoneuroimmunology (PNI) and microbiome-gut-brain axis research in PWH. Results: Early PNI studies demonstrated that neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis and autonomic nervous system could partially account for the associations of psychological factors with clinical HIV progression. This review highlights the need for PNI studies examining the mechanistic relevance of the gut microbiota for residual immune dysregulation, tryptophan catabolism, and oxytocin release as key biological determinants of neuropsychiatric comorbidities in PWH (i.e., body-to-mind pathways). It also underscores the continued relevance of neuroendocrine signaling via the hypothalamic-pituitary-adrenal axis, autonomic nervous system, and oxytocin release in modifying microbiome-gut-brain axis functioning (i.e., mind-to-body pathways). Conclusions: Advancing our understanding of PNI and microbiome-gut-brain axis pathways relevant to depression, substance use disorders, and other neuropsychiatric comorbidities in PWH can guide the development of novel biobehavioral interventions to optimize health outcomes. Recommendations are provided for biobehavioral and neurobehavioral research investigating bidirectional PNI and microbiomegut-brain axis pathways among PWH in the modern antiretroviral therapy era.

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Overamped: Stimulant Use and HIV Pathogenesis

Ross,

Williams,

Viamonte

et al. 2023

Curr HIV/AIDS Rep

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Tryptophan depletion predicts lower positive affect in sexual minority men living with HIV who use methamphetamine

Cited by 5 publications

References 34 publications

Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV

Higher Soluble CD163 in Blood Is Associated With Significant Depression Symptoms in Men With HIV

Through the Looking-Glass: Psychoneuroimmunology and the Microbiome-Gut-Brain Axis in the Modern Antiretroviral Therapy Era

Overamped: Stimulant Use and HIV Pathogenesis

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