Tryptase expression as a prognostic marker in patients with resected gastric cancer

Lin, Chao; Liu, H; Zhang, H; Cao, Yuxue; Li, R; Wu, Siyu; Li, Hankun; He, Hongwei; Xu, Jiacheng; Sun, Yandong

doi:10.1002/bjs.10546

Cited by 15 publications

(17 citation statements)

References 32 publications

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“…Tumor immune signatures have provided enormous information regarding the status of tumor immune surveillance and the choice of immunotherapy [24][25][26]. By comparing the immunocytes infiltration between high and low IL17A groups, we revealed the fact that tumors with high IL17A mRNA and IL17A þ cells had higher antitumor mast cells [27], NK cells [28,29], and lower pro-tumor M2 [30] infiltration. These data suggested that IL17A þ cells in gastric cancer may function by influencing the infiltration of other immunocytes.…”

Section: Discussionmentioning

confidence: 91%

Intratumoral IL17-producing cells infiltration correlate with antitumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer

Wang

Zhang

et al. 2019

Annals of Oncology

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Background: Tumor IL17-producing (IL17A þ) cells infiltration has different prognostic values among various cancers. The objective of this study was to assess the effect of IL17A þ cells in gastric cancer. Patients and methods: The study included two patient cohorts, the Cancer Genome Atlas cohort (TCGA, n ¼ 351) and the Zhongshan Hospital cohort (ZSHC, n ¼ 458). The TCGA and ZSHC were used for mRNA-related and cells infiltration-related analyses, respectively. The roles of IL17A mRNA and IL17A þ cells in overall survival (OS), response to adjuvant chemotherapy (ACT), and immune contexture were evaluated. Another independent cohort was included to identify the correlation between mRNA of IL17A and IL17A þ cells infiltration (the preliminary Zhongshan Hospital cohort, PZSHC, n ¼ 21). Results: The infiltration of IL17A þ cells was positively correlated with the expression of IL17A mRNA (Spearman's q ¼ 0.811; P < 0.001). High IL17A mRNA expression and intratumoral IL17A þ cells were correlated with improved OS and remained to be significant after adjusted for confounders. Patients with TNM II/III disease whose tumor present higher intratumoral IL17A þ cells or lower peritumoral IL17A þ cells can benefit more from ACT. Elevated IL17A mRNA expression and increased intratumoral IL17A þ cells infiltration was associated with more antitumor mast cells and nature killer cells infiltration and less pro-tumor M2 macrophages infiltration. High IL17A mRNA expression represented a Th17 cells signature and immune response process and was correlated with increased cytotoxic GZMA, GZMB, IFNG, PRF1, and TNFSF11 expression. Conclusions: IL17A mRNA expression and intratumoral IL17A þ cells infiltration were correlated with antitumor immune contexture. IL17A þ cells infiltration could be used as an independent prognostic biomarker for OS and predictive biomarker for superior response to ACT, and further prospective validation needs to be conducted.

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Section: Discussionmentioning

confidence: 91%

Intratumoral IL17-producing cells infiltration correlate with antitumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer

Wang

Zhang

et al. 2019

Annals of Oncology

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“…Although most tumors evade immune surveillance at the time of presentation, the residual signs of active anticancer immune response present a favorable prognosis . High TIM density is associated with positive prognosis in some tumors . It is reported that TIM arrest the growth and induce apoptosis of breast cancer through secretion of IL‐4 .…”

Section: Discussionmentioning

confidence: 99%

“…9,20 High TIM density is associated with positive prognosis in some tumors. 10,13,21 It is reported that TIM arrest the growth and induce apoptosis of breast cancer through secretion of IL-4. 22 In the current study, we observed that TIM were positively correlated with prolonged OS.…”

Section: Discussionmentioning

confidence: 99%

“…Tumor‐infiltrating mast cells (TIM) accumulate in the TME in the early stages, and the infiltration of TIM is generally correlated with poor prognosis in multiple malignant tumors . However, in human kidney cancer and gastric cancer, the accumulation of TIM is associated with favorable prognosis . Although it is reported that mast cells can directly inhibit tumor progression by releasing mediators such as TNF and heparin, mast cells can also generate effective anti–tumor immunity by recruiting and activating the immune cells in the TME, including natural killer (NK) cells, CD8+ T cells and dendritic cells .…”

Section: Introductionmentioning

confidence: 99%

“…10,11 However, in human kidney cancer and gastric cancer, the accumulation of TIM is associated with favorable prognosis. 12,13 Although it is reported that mast cells can directly inhibit tumor progression by releasing mediators such as TNF and heparin, mast cells can also generate effective anti-tumor immunity by recruiting and activating the immune cells in the TME, including natural killer (NK) cells, CD8+ T cells and dendritic cells. 10,14,15 Recent studies have suggested that mast cells recruit T cells at sites of inflammation by secreting CCL3, CCL5, CXCL10 and LTB 4 .…”

Section: Introductionmentioning

confidence: 99%

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High infiltration of mast cells is associated with improved response to adjuvant chemotherapy in gallbladder cancer

Wang

et al. 2020

Cancer Science

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Recent studies have reported that tumor‐infiltrating mast cells (TIM) play an important role in tumor regression, but the effect of TIM in gallbladder cancer (GBC) remains unclear. The present study aims to investigate the prognostic value of TIM in GBC patients and its responsiveness to gemcitabine‐based adjuvant chemotherapy (ACT). A total of 298 GBC patients from Zhongshan Hospital were recruited for this study. TIM infiltration was measured by immunohistochemical staining. Accumulation of TIM is significantly associated with prolonged overall survival in GBC patients. The benefit from gemcitabine‐based ACT was superior among patients with high infiltration of TIM with GBC. Multivariate analysis identified TIM infiltration as an independent prognostic factor for overall survival. A heatmap showed that TIM‐activated gene signatures were positively correlated with CD8+ T cells' gene signatures. Gene set enrichment analysis (GSEA) suggested that TIM was related to multiple T cell‐related processes and signaling pathways, including the interferon gamma signaling pathway and the leukocyte migration signaling pathway. It was confirmed that CD8+ T cell infiltration was positively correlated with high TIM infiltration in tissue microarray (TMA), suggesting that TIM infiltration was linked to the immune surveillance in GBC. TIM can be used as an independent prognostic factor and a predictor of therapeutic response of gemcitabine‐based ACT in GBC patients, which may mediate immune surveillance by recruiting and activating CD8+ T cells in GBC.

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Mast Cells in the Tumor Microenvironment

Aponte-López

Muñoz-Cruz

2020

Advances in Experimental Medicine and Biology

102

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Tryptase expression as a prognostic marker in patients with resected gastric cancer

Abstract: Tryptase expression is an independent prognostic factor for overall and recurrence-free survival in patients with gastric cancer after surgical resection.

Cited by 15 publications

References 32 publications

Intratumoral IL17-producing cells infiltration correlate with antitumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer

Intratumoral IL17-producing cells infiltration correlate with antitumor immune contexture and improved response to adjuvant chemotherapy in gastric cancer

High infiltration of mast cells is associated with improved response to adjuvant chemotherapy in gallbladder cancer

Mast Cells in the Tumor Microenvironment

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