Tryptanthrin Reduces Campylobacter jejuni Colonization in the Chicken Gut by a Bactericidal Mechanism

Abstract

Campylobacter is a widespread pathogen in the food chain of chickens. Once chickens become infected, large numbers of Campylobacter cells are excreted in their feces.

Tryptanthrin Analogs Substoichiometrically Inhibit Seeded and Unseeded Tau4RD Aggregation

“…25,26 With this discovery pipeline, we now identify the tryptanthrin (TA) family as potent, substoichiometric inhibitors of tau4RD aggregation. Though TA, a plant alkaloid, is known to have anti-microbial, [27][28][29][30] anti-inflammatory, 31,32 anti-fungal, 33,34 and anti-cancer activity, [35][36][37][38] our work is the first demonstration of TA as an anti-amyloid agent. Here we describe the SAR of TA analogs against tau4RD aggregation and identify the mechanism by which they inhibit aggregation.…”

Acinetobacter baumannii biofilm was inhibited by tryptanthrin through disrupting its different stages and genes expression

“…The natural product tryptanthrin is a promising drug candidate for leishmaniasis treatment . 21 Tryptanthrin has antifungal activity against Cryptococcus species by interfering with the cell cycle, 22 Taketoshi Iwata, etc., found that tryptanthrin has potential for anti- C. jejuni activity, 23 and Lekshmi Narendrakumar’s research showed that tryptanthrin has strong antibiofilm activity at sub-MICs (MIC = 2 μg/mL) against V. cholera . 26 Therefore, we investigated whether tryptanthrin can inhibit or disrupt biofilm formation in A. baumannii .…”

“… 20 In addition, the antiparasitic and antibacterial activities of tryptanthrin were also found. Tryptanthrin can protect against leishmaniasis 21 and Cryptococcus species by interfering with the cell cycle; 22 against Campylobacter jejuni ; 23 against Helicobacter pylori through an infected Mongolian gerbil assay; 24 against methicillin-resistant Staphylococcus aureus (MRSA) of Couroupita guianensis ; 25 and against Vibrio cholerae by inhibiting biofilms. 26 To date, there has been no research on the effect of tryptanthrin on A. baumannii .…”

Recent Advances in Current Uptake Situation, Metabolic and Nutritional Characteristics, Health, and Safety of Dietary Tryptophan

“…AhR activation was reported to be associated with certain types of Zika and Dengue viruses, while AhR antagonists activate antiviral immunity, reduce viral load, and improve Zika virus-induced pathology in vivo . Some studies have shown that the timed killing experiments with undergrowth and nongrowth conditions indicate that Trp has a narrow-spectrum antibacterial effect on C. jejuni …”

“…99 Some studies have shown that the timed killing experiments with undergrowth and nongrowth conditions indicate that Trp has a narrow-spectrum antibacterial effect on C. jejuni. 100 The investigations of tuberculosis patients, 101 HIV-positive, HIV-negative, bacterial meningitis, and cryptococcal meningitis patients were carried out in combination with HPLC-MS analysis of Trp metabolism in cerebrospinal fluid. 6 The results showed that cerebrospinal fluid Trp levels were associated with 60-day mortality in tuberculous meningitis, and HIV-positive patients with high baseline cerebrospinal fluid Trp values or high systemic (plasma) KYN levels were at increased risk of death.…”