Tryptamine as an endogenous modulator of neuronal sensitivity to serotonin

Komissarov, I. V.; Абрамец, И. И.; Samoilovich, I. M.

doi:10.1007/bf01058225

Cited by 4 publications

(1 citation statement)

References 13 publications

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“…1. Also tryptamine, a derivative of 5-HT found in trace amounts in the brains of mammals is believed to play a role as a neuromodulator or neurotransmitter [12]. Tryptamine is also the backbone for a group of compounds collectively known as tryptamines showing bioactivity including neurotransmitter and psychotropic properties [13].…”

Section: Introductionmentioning

confidence: 99%

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Dragulska

Kańska

2014

Nukleonika

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Abstract. The enzymatic deamination of 5-fl uorotryptamine and 5-hydroxytryptamine, 5-HT, catalysed by enzyme monoamine oxidase A (MAO-A, EC 1.4.3.4) was investigated using the kinetic (KIE) and solvent (SIE) isotope effects methods. The numerical values of deuterium isotope effects in the (1R) positions of 5-F-tryptamine were determined using non-competitive spectrophotomeric method. Isotopologue 5-F-[(1R)--2 H]-tryptamine, needed for kinetic studies was obtained by enzymatic decarboxylation of 5-fl uoro-L-tryptophan, 5-F-L-Trp, in fully deuteriated medium.

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Section: Introductionmentioning

confidence: 99%

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Dragulska

Kańska

2014

Nukleonika

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Quantum chemical (QM:MM) investigation of the mechanism of enzymatic reaction of tryptamine and N,N-dimethyltryptamine with monoamine oxidase A

Kubicskó

Farkas

2020

Org. Biomol. Chem.

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Isotope effects in the enzymatic oxidation of tryptamine to 3-indolyl-acetaldehyde

Dragulska

Winnicka

Kańska

2014

Isotopes in Environmental and Health Studies

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The reaction mechanisms of the enzymatic deamination of tryptamine catalysed by the enzyme monoamine oxidase (MAO, EC 1.4.3.4) were investigated using the kinetic isotope effect and solvent isotope effect methods. The numerical values of these deuterium effects in the (1S) and (1R) positions of tryptamine were determined using the non-competitive spectrophotometry. The deuterium-labelled isotopologue [(1S)-(2)H]tryptamine was obtained in two steps by enzymatic coupling of indole with S-methyl-l-cysteine in a deuterated medium followed by enzymatic decarboxylation of the resulting [2-(2)H]-l-tryptophan. [(1R)-(2)H]tryptamine was obtained by enzymatic decarboxylation of l-tryptophan in the fully deuterated medium.

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Tryptamine as an endogenous modulator of neuronal sensitivity to serotonin

Cited by 4 publications

References 13 publications

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Enzymatic oxidation of substituted tryptamines catalysed by monoamine oxidase

Quantum chemical (QM:MM) investigation of the mechanism of enzymatic reaction of tryptamine and N,N-dimethyltryptamine with monoamine oxidase A

Isotope effects in the enzymatic oxidation of tryptamine to 3-indolyl-acetaldehyde

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