Trypsin, Rutoside and Bromelain Alone and Fixed Dose Combination: A Natural, Safer and Effective Anti-Inflammatory Agent

Kaur, Rimple Jeet; Abmwani, Sneha; Mehta, Bharati

doi:10.22270/jddt.v4i1.746

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…In patients with osteoarthritis, it has been used as an alternative to nonsteroidal anti-inflammatory drugs (NSAIDs). [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars

Singh¹,

Fatima³

et al. 2016

J Int Soc Prevent Communit Dent

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Aims and Objectives:To evaluate the effect of bromelain on pain and swelling after surgical removal of third molars.Materials and Methods:A prospective randomized clinical study was conducted among 40 patients requiring surgical removal of impacted mandibular third molars. All the impacted molars were surgically removed, and the patients were administered bromelain along with amoxicillin. Patients were recalled on day 1, day 3, and day 7 for postoperative pain assessment using visual analogue scale (VAS) and postoperative swelling assessment using facial reference points tragus and pogonion. VAS score was statistically analyzed using repeated analysis of variance with post-hoc Bonferroni test postoperatively on day 1, day 3, and day 7 using the Statistical Package for the Social Sciences software version 14.Results:Out of the total 40 patients, bromelain was effective in 28 (70%) patients. In these patients, there was reduction in swelling and pain after taking bromelain.Conclusion:Bromelain can be used as a successful oral enzyme therapy for oral surgery patients, especially after removal of impacted third molars.

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“…In patients with osteoarthritis, it has been used as an alternative to nonsteroidal anti-inflammatory drugs (NSAIDs). [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars

Singh¹,

Fatima³

et al. 2016

J Int Soc Prevent Communit Dent

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“…This efficacy of bromelain was investigated by administering a combination of bromelain, trypsin and rutoside to 51 patients. As a control, diclofenac, one of the most commonly used NSAIDs, was administered to 52 other patients . Both treatments led to substantial and comparable reductions in pain and inflammation within 6 weeks of consumption .…”

Section: Commercialisation Of Bromelainmentioning

confidence: 99%

Bromelain: from production to commercialisation

2016

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Bromelain is a mixture of proteolytic enzymes found in pineapple (Ananas comosus) plants. It can be found in several parts of the pineapple plant, including the stem, fruit, leaves and peel. High demand for bromelain has resulted in gradual increases in bromelain production. These increases have led to the need for a bromelain production strategy that yields more purified bromelain at a lower cost and with fewer production steps. Previously, bromelain was purified by conventional centrifugation, ultrafiltration and lyophilisation. Recently, the development of more modern purification techniques such as gel filtration, ion exchange chromatography, affinity chromatography, aqueous two-phase extraction and reverse micelle chromatography has resulted in increased industrial bromelain production worldwide. In addition, recombinant DNA technology has emerged as an alternative strategy for producing large amounts of ultrapure bromelain. An up-to-date compilation of data regarding the commercialisation of bromelain in the clinical, pharmaceutical and industrial fields is provided in this review. © 2016 Society of Chemical Industry.

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“…[8][9][10] Bromelain is used instead of NSAIDs in patients with osteoarthritis. 11 Majid and Al-Mashhadani 12 evaluated the effect of oral bromelain versus oral diclofenac sodium with placebo on pain, quality of life, swelling, and trismus after the surgical removal of impacted lower third molars. The individuals who had used diclofenac and bromelain had considerably lower mean pain scores than those using a placebo.…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery: A crossover randomized clinical trial

Faramarzi

Sadighi

Shirmohamadi

et al. 2023

J Adv Periodontol Implant Dent

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Background. This study aimed to compare the analgesic effects of Ibuprofen and bromelain after periodontal surgery. Methods. A double-blinded crossover clinical trial was conducted on 22 patients needing two crown lengthening surgeries without bone surgery or with limited bone surgery on two quadrants of the maxilla, with control and test sides. Each quadrant was randomly assigned to bromelain (500 GUD) or ibuprofen (400 mg). Immediately after the surgery and 6 hours after it, the first dose of the drugs was packaged in the same capsules in A and B. Postoperative pain was evaluated during the first 8 hours and on the following day using a visual analog scale (VAS). Results. Using the VAS, the Ibuprofen group showed significantly lower mean pain scores than the bromelain group at 4 hours (P=0.047). In contrast, there were no significant differences between the two groups at 2, 6, 8, 10, 12, 24, and 48 hours (P>0.05). Conclusion. The effectiveness of bromelain for pain control following periodontal surgery was comparable to that of Ibuprofen. Therefore, bromelain can be an efficient replacement for ibuprofen in managing pain after periodontal surgery, especially in patients with gastric ulceration and increased bleeding tendency.

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Trypsin, Rutoside and Bromelain Alone and Fixed Dose Combination: A Natural, Safer and Effective Anti-Inflammatory Agent

Cited by 5 publications

References 18 publications

Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars

Effect of proteolytic enzyme bromelain on pain and swelling after removal of third molars

Bromelain: from production to commercialisation

Effectiveness of Bromelain in the control of postoperative pain after periodontal surgery: A crossover randomized clinical trial

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