Trypsin, Invertase and Amylase Content of Feces of Germfree Rats.

Borgström, Bengt; Dahlqvist, Arne; Gustafsson, Bengt E.; Lundh, G; Malmquist, Jörgen

doi:10.3181/00379727-102-25174

Cited by 53 publications

(11 citation statements)

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“…This was suggested by the experiment where infected rats were fed diet 300 for 26 days and the level of smooth surface lesions observed was sevenfold lower than occurred in infected animals fed diet 305 for the same length of time. That infected rats fed diet 300 for 26 days developed some lesions was not unexpected, since rats have alpha-amylases in saliva and the gut which can hydrolyze starch to glucose and maltose components (1,26,33).…”

Section: Fig 2 (A)mentioning

confidence: 99%

Virulence of Streptococcus mutans: a sensitive method for evaluating cariogenicity in young gnotobiotic rats

Michalek¹,

McGhee²,

Navia³

1975

Infect Immun

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Gnotobiotic rats infected with Streptococcus mutans 6715 at 19 days of age and fed a purified diet (305) containing 5% sucrose developed extensive caries lesions on all molar surfaces within 16 days (35 days of age). Approximately twice as many lesions developed when infected rats were maintained until 45 days of age, whereas noninfected rats did not develop caries when fed diet 305. Gnotobiotic rats infected with S. mutans 6715 and fed a purified diet containing no sucrose (300) until day 25 and subsequently fed diet 305 for 10 days developed lesions similar to rats fed diet 305 for 16 days. Furthermore, rats infected with S. mutans 6715 and fed diet 300 until 45 days of age developed approximately one-half the smooth surface lesions as infected rats fed diet 305 for the same length of time. The level of caries on buccal and proximal molar surfaces in 45-day-old gnotobiotic rats varied when animals were infected with S. mutans AHT, BHT, NCTC 10449, 6715, or LM-7. Animals infected with S. mutans AHT showed more severe lesions on the buccal surfaces than those observed in animals infected with the other strains of S. mutans tested, whereas S. mutans 6715 caused significantly more caries on proximal surfaces. On the other hand, rats infected with S. mutans LM-7 exhibited the lowest level of caries on all molar surfaces of the five strains of S. mutans tested.

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Section: Fig 2 (A)mentioning

confidence: 99%

Virulence of Streptococcus mutans: a sensitive method for evaluating cariogenicity in young gnotobiotic rats

Michalek¹,

McGhee²,

Navia³

1975

Infect Immun

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“…The present consensus regarding the fate of the pancreatic proteases trypsin and chymotrypsin in the human intestinal tract rests largely upon experiments by Borgstrom, Dahlqvist, Lundh, and Sjovall (1957), who measured their activity in juice obtained by intubation of the small intestine. The results indicated a progressive fall in activity from the pylorus towards the ileocaezal valve.…”

mentioning

confidence: 99%

“…Support for their conclusion that enzyme degradation takes place in the small intestine has come from Pelot and Grossman (1962), who demonstrated rapid inactivation of pancreatic enzymes in the rat. Studies in this laboratory have shown binding of trypsin and chymotrypsin to human intestinal cells (Goldberg, Campbell, and Roy, 1968a), and have demonstrated that the spectrophotometric assay of Lundh (1957), as used by Borgstrom et al (1957), was incapable of estimating bound enzymes. An alternative possibility was that the enzymes became bound to the surface of cells during transit through the intestine and to components of intestinal debris.…”

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confidence: 99%

Fate of trypsin and chymotrypsin in the human small intestine.

Goldberg¹,

Campbell²,

Roy³

1969

Gut

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“…Mucoproteins and enzymes secreted by the pancreas comprise a high pro portion of the endogenous protein N in the lower gut. Microbial degradation of mucoproteins and inactivation of trypsin and chymotrypsin in the GF rat cecum have been reported by BoRGSROM et al (24) and LINDSTEDT et al (25). COMBE (26) reported a study of endogenous N in the digestive contents of GF and CV rats by 14C amino acid.…”

Section: Discussionmentioning

confidence: 78%