TrypInDB: A searchable online resource of small molecule inhibitors against Trypanosoma sp.

Vijayakumar, Saravanan; Ranjan, Ravi; Kumar, Rishikesh; Das, Pradeep

doi:10.1016/j.parint.2020.102131

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…gov/), and the recently curated TrypInDB (http://trypindb. biomedinformri.com/; Vijayakumar et al, 2020). Likewise, we propose the formulation of a virtual library/database to contain the 93 highlighted antiparasitic natural products of Nigerian origin, as well as information on all tested but inactive natural compounds in order to minimize needless replication, and continue to expand the library as new pharmacologically active compounds are being discovered.…”

Section: Formulate a Virtual Library Of The Compoundsmentioning

confidence: 99%

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora

et al. 2020

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The West African country Nigeria features highly diverse vegetation and climatic conditions that range from rain forest bordering the Atlantic Ocean in the South to the Desert (Sahara) at the Northern extreme. Based on data from the World Conservation Monitoring Center of the United Nations Environmental Protection, Nigeria, with ~5,000 documented vascular plants, ranks amongst the top 50 countries in terms of biodiversity. Such a rich biodiversity implies that the country is rich in diverse secondary metabolites—natural products/unique chemicals produced by the plant kingdom to confer selective advantages to them. Like many tropical countries, Nigeria is also endemic to numerous infectious diseases particularly those caused by parasitic pathogens. These phytochemicals have been exploited for the treatment of diseases and as a result, a new branch of chemistry, natural product chemistry, has evolved, to try to reproduce and improve the therapeutic qualities of particular phytochemicals. In this review, we have compiled a compendium of natural products, isolated from Nigerian flora, that have been reported to be effective against certain protozoan parasites with the aim that it will stimulate interests for further investigations, and give impetus to the development of the natural products into registered drugs. In total 93 structurally characterized natural compounds have been identified with various levels of anti-parasite activity mainly from Nigerian plants. The synthesis protocol and molecular target for some of these natural anti-parasite agents have been established. For instance, the anti-plasmodial compound fagaronine (7), a benzophenanthridine alkaloid from Fagara zanthoxyloides has been successfully synthesized in the laboratory, and the anti-trypanosomal compound azaanthraquinone (55) elicits its effect by inhibiting mitochondrial electron transfer in trypanosomes. This review also discusses the barriers to developing approved drugs from phytochemicals, and the steps that should be taken in order to accelerate the development of new antiparasitics from the highlighted compounds.

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Section: Formulate a Virtual Library Of The Compoundsmentioning

confidence: 99%

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora

et al. 2020

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“…Additionally, a substructure search feature, a dynamic search across a number of fields, and the ability to download all of the molecule structures that match the search criteria were included. Active links exist between each target enzyme and TriTrypDB (Vijayakumar et al, 2020). The user can perform simple text searches to complicated searches with numerous range values, fields and dynamic chemical substructures using the simple graphical user interface of the LeishInDB portal.…”

Section: Leishmania Inhibitor Database (Leishindb)mentioning

confidence: 99%

Databases and web resources for neglected tropical disease research

Arya¹,

Barik²,

Singh³

et al. 2023

J Appl Pharm Sci

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The term "neglected tropical diseases" (NTDs) refers to a group of infectious diseases that are common in developing tropical and subtropical nations. There are 20 such diseases that are prevalent in 149 countries according to the World Health Organization. These diseases have a devastating impact on the economies of affected countries and result in enormous losses in terms of morbidity and mortality. All NTDs need to receive more attention to prevent widespread epidemics and outbreaks that could result in a high death toll globally. The few drugs that are already on the market are no longer effective against many infectious diseases, and various other problems, such as toxicity and pharmacokinetics concerns, also prohibit the eradication of these diseases. One of the crucial steps in the drug discovery pipeline is the identification and validation of a therapeutic target based on the biology of the organism. This review provides an overview of more than 35 web-accessible NTD databases categorized under general, specialized, and other NTD databases and highlights recent advances. These databases can be very useful for research, especially drug design and discovery against NTDs. The majority of these databases are simple to use and freely accessible online.

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TrypInDB: A searchable online resource of small molecule inhibitors against Trypanosoma sp.

Cited by 2 publications

References 29 publications

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora

A Review of the Antimalarial, Antitrypanosomal, and Antileishmanial Activities of Natural Compounds Isolated From Nigerian Flora

Databases and web resources for neglected tropical disease research

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