Trypanosomosis and phenotypic features of four indigenous cattle breeds in an Ethiopian field study

Stein, Jennie; Ayalew, W.; Rege, Ed; Mulatu, W.; Lemecha, H.; Tadesse, Yaregal; Tekle, T.; Philipsson, J.

doi:10.1016/j.vetpar.2010.12.025

Cited by 23 publications

(29 citation statements)

References 7 publications

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“…This observation is in accordance with the currently available information indicating the trypanocidal effects of treatment with Veridium ® in cattle (Stevenson et al, 2000). Delaying of Veridium ® treatment by 45 days after the administration of Diminasan ® was a reasonable process in light with the possible side effects that could be associated with the injection of the second drug in a short period following the administration of the first (Eisler et al, 2001;Stein et al, 2011;Mungube et al, 2012). The sensitivity of the isolates to Veridium ® is conclusive.…”

Section: Discussionsupporting

confidence: 89%

“…A useful study that assessed this important issue was conducted in the Ghibe valley, where T. congolense strains demonstrated multiple resistance to all available drugs. In that study, it was deduced that, despite the occurrence of high degrees of drug resistance, local zebu cattle could yield profitable productivity, so that attractive economic returns were generated for herd owners (International Livestock Research Institute (ILRI), 2002;Stein et al, 2011;Moti et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…T. congolense isolated from Konso district Southern Ethiopia exhibited resistance to Diminasan ® , which could also be Veridium ® . However, this need to be confirmed by deriving clones from the trypanosome population in cattle or mice (Eisler et al, 2001;Stein et al, 2011). Nevertheless, the chemotherapy is still the most convenient way of fighting against the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Control of animal trypanosomosis is one of the key components to improve the productive opportunities of rural communities in tsetse-infested areas. This has been addressed using trypanocidal drugs which are limited in number and have been under extensive use for over 40 years with little or no regular monitoring (Stein et al, 2011;Chitanga et al, 2011;Mungube et al, 2012;Sow et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Ashenafi¹,

Gewado²,

Hailu³

2014

J. Vet. Med. Anim. Health

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Study on sensitivity to diminazene aceturate 3.5 mg/kg and isometamidium chloride 0.5 mg/kg in tenzebu calves experimentally infected with two field isolates of Trypanosoma congolense (ET/07/Konso 59 and ET/07/Konso 114) was undertaken in Konso district, Southern Ethiopia. Calves were monitored for clinical and parasitological parameters during three months. At day 15 postinfection, corresponding to peak parasitaemia, they were treated with Diminasan ® 3.5 mg/kg body weight via deep intramuscular route. Out of ten calves, only two remained parasitologically negative for 12 and 15 days after treatment with Diminasan ® . Once relapse/breakthrough infection was detected in two calves, parasitemia persisted until they get second treatment with Veridium ® 0.5 mg/kg body weight. However, linear regression analysis of the effects of persistent trypanosomal infections on mean packed cell volume (PCV) and loss of body condition in relation to the initial recordings in the relapsed calves was not statistically significant. Results of the trypanocidal drug sensitivity study revealed the presence of T. congolense populations exhibiting resistance to diminazene aceturate. It is strongly recommended that legislations be devised and implemented to ensure that only quality and effective trypanocidal drugs should get access to the market.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Ashenafi¹,

Gewado²,

Hailu³

2014

J. Vet. Med. Anim. Health

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“…The genome-wide SNP data generated for these populations will facilitate subsequent scanning of genomic regions under selection, and will enable a better understanding of the evolutionary forces that shape the genetic constitution of populations. Sheko cattle, which are the only remnants of East African shorthorn taurine (Rege, 1999) populations, are known to adapt to humid climatic conditions and have some level of tolerance for trypanosomiasis (Stein et al, 2011). However, as was clearly portrayed in our study, Sheko cattle are undergoing strong genetic admixture with local cattle populations.…”

Section: Discussionmentioning

confidence: 49%

Genome-wide genetic diversity, population structure and admixture analysis in African and Asian cattle breeds

Edea

Bhuiyan

Dessie³

et al. 2015

Animal

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Knowledge about genetic diversity and population structure is useful for designing effective strategies to improve the production, management and conservation of farm animal genetic resources. Here, we present a comprehensive genome-wide analysis of genetic diversity, population structure and admixture based on 244 animals sampled from 10 cattle populations in Asia and Africa and genotyped for 69 903 autosomal single-nucleotide polymorphisms (SNPs) mainly derived from the indicine breed. Principal component analysis, STRUCTURE and distance analysis from high-density SNP data clearly revealed that the largest genetic difference occurred between the two domestic lineages (taurine and indicine), whereas Ethiopian cattle populations represent a mosaic of the humped zebu and taurine. Estimation of the genetic influence of zebu and taurine revealed that Ethiopian cattle were characterized by considerable levels of introgression from South Asian zebu, whereas Bangladeshi populations shared very low taurine ancestry. The relationships among Ethiopian cattle populations reflect their history of origin and admixture rather than phenotype-based distinctions. The high within-individual genetic variability observed in Ethiopian cattle represents an untapped opportunity for adaptation to changing environments and for implementation of within-breed genetic improvement schemes. Our results provide a basis for future applications of genome-wide SNP data to exploit the unique genetic makeup of indigenous cattle breeds and to facilitate their improvement and conservation.

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Transition from Forest‐based to Cereal‐based Agricultural Systems: A Review of the Drivers of Land use Change and Degradation in Southwest Ethiopia

et al. 2016

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The southwestern Ethiopian montane forests are one of the most species‐rich ecosystems and are recognised globally as a priority area for the conservation of biodiversity. Particularly, in contrast to the drier central and northern Ethiopian highlands, they have received little attention by researchers. Here, we review changes to agricultural systems in and around these forests that are known as the genetic home of coffee (Coffea arabica L.) and that are important to the livelihoods of many rural people who have developed traditional management practices based on agro‐ecological knowledge, religious taboos and customary tenure rights. We explored the impacts of conversions to agroforestry and cereal‐based cropping systems on biodiversity, soil fertility, soil loss and the socio‐economic conditions and culture. The increasing trend of cereal cropping, resettlement and commercial agriculture causes the deterioration of natural forest cover in the region and threatens biodiversity, land quality, sustainable, traditional farming practices and the livelihood of the local community. Large‐scale plantations of tea, coffee, soapberry locally known as endod (Phytolacca dodecandra L'Hér.) and cereals have resulted in biodiversity loss. Following the conversion of forests, cultivated fields exhibit a significant decline in soil fertility and an increase in soil loss as compared with the traditional agroforestry system. The establishment of a sustainable agricultural system will require a change in paradigm, whereby the intrinsic values of the traditional forest‐based agricultural system are recognised, rather than the ongoing mimicking of agricultural policies that were developed for the open fields of central Ethiopia. Copyright © 2016 John Wiley & Sons, Ltd.

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Trypanosomosis and phenotypic features of four indigenous cattle breeds in an Ethiopian field study

Cited by 23 publications

References 7 publications

Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Sensitivity of Trypanosoma congolense field isolates in experimentally infected calves in Konso district, Southern Ethiopia to isomethamidium and diminazene

Genome-wide genetic diversity, population structure and admixture analysis in African and Asian cattle breeds

Transition from Forest‐based to Cereal‐based Agricultural Systems: A Review of the Drivers of Land use Change and Degradation in Southwest Ethiopia

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