Trypanosoma seryl-tRNA synthetase is a metazoan-like enzyme with high affinity for tRNASec.

Geslain, Renaud; Aeby, Eric; Guitart, Tanit; Jones, T. H.; M, Castro de Moura; Charrière, Fabien; Schneider, André; L, Ribas de Pouplana

doi:10.1074/jbc.a607862200

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Sequence Conservation Analysis1

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2021

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“…Analysis of the trees indicates that in all cases but two (MetRS and mt-LysRS), trypanosomatid sequences of aaRSs clustered within cytosolic sequences from eukaryotes and archaeal sequences, revealing the eukaryotic-type origin of trypanosomatids aaRSs. This confirms existing sparse observations made with case-by-case studies (11,12,27) and is in agreement with the fact that all tRNAs, including the mitochondriallytargeted ones, are of the eukaryotic type (7,8). S3).…”

Section: Sequence Conservation Analysissupporting

confidence: 90%

Peculiarities of aminoacyl-tRNA synthetases from trypanosomatids

Parrot

Moulinier

Bernard

et al. 2021

Journal of Biological Chemistry

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