Trypanosoma cruzi Infection in Non-Human Primates

Sathler-Avelar, Renato; Mattoso-Barbosa, Armanda Moreira; Martins-Filho, OlindoAssis; Teixeira-Carvalho, Andréa; MarchettiVitelli-Avelar, Danielle; VandeBerg, John L.; VandeBerg, Jane F.

doi:10.5772/intechopen.71652

Cited by 2 publications

(3 citation statements)

References 37 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These characteristics are similar to those of Chagas disease in humans. The myocardium, muscle fibers, or esophagus may also be affected and may accompanied by arrythmia or esophageal dilatation [181][182][183][184][185][186] .…”

Section: Other Protozoa: Trypanosoma Spp (Flagellates)mentioning

confidence: 99%

Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies

Ohta

2023

J Toxicol Pathol

View full text Add to dashboard Cite

Nonhuman primates (NHPs), which have many advantages in scientific research and are often the only relevant animals to use in assessing the safety profiles and biological or pharmacological effects of drug candidates, including biologics. In scientific or developmental experiments, the immune systems of animals can be spontaneously compromised possibly due to background infection, experimental procedure-associated stress, poor physical condition, or intended or unintended mechanisms of action of test articles. Under these circumstances, background, incidental, or opportunistic infections can seriously can significantly complicate the interpretation of research results and findings and consequently affect experimental conclusions. Pathologists and toxicologists must understand the clinical manifestations and pathologic features of infectious diseases and the effects of these diseases on animal physiology and experimental results in addition to the spectrum of infectious diseases in healthy NHP colonies. This review provides an overview of the clinical and pathologic characteristics of common viral, bacterial, fungal, and parasitic infectious diseases in NHPs, especially macaque monkeys, as well as methods for definitive diagnosis of these diseases. Opportunistic infections that can occur in the laboratory setting have also been addressed in this review with examples of cases of infection disease manifestation that was observed or influenced during safety assessment studies or under experimental conditions.

show abstract

Section: Other Protozoa: Trypanosoma Spp (Flagellates)mentioning

confidence: 99%

Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies

Ohta

2023

J Toxicol Pathol

View full text Add to dashboard Cite

show abstract

“…The most common way of transmission of Trypanosoma spp. is through an invertebrate vector (Zabalgoitia et al 2003, Sathler-Avelar et al 2017, Jansen et al 2018, Drozino et al 2019. Capuchin monkeys and marmosets have a habit of sleeping in tangles of vines, bromeliads, and in the base of palm leaves, places where the vector may be present.…”

Section: Discussionmentioning

confidence: 99%

“…Capuchin monkeys and marmosets have a habit of sleeping in tangles of vines, bromeliads, and in the base of palm leaves, places where the vector may be present. Oral transmission in Neotropical species seems relevant (Zabalgoitia et al 2003, Sathler-Avelar et al 2017, since their insect-eating habits May predispose these animals to ingest infected triatomines or other bugs (Zabalgoitia et al 2003, Sathler-Avelar et al 2017.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection and phylogenetic analysis of Trypanosoma spp. in Neotropical primates from Rio de Janeiro State, Brazil

et al. 2022

View full text Add to dashboard Cite

Trypanosoma spp. infection is a problem in many tropical countries, infecting several animal species, including humans. The aim of the present study was to identify the Trypanosoma species in Neotropical primates from Rio de Janeiro state and compare the results with other reports both phylogenetically and geographically. Molecular detection was based on the 18 SSU gene. The sequences obtained in the PCR were sequenced and compared with others previously deposited in GenBank. These sequences were used to perform phylogenetic analysis and make a distribution map of primate species infected by Trypanosoma species in Brazil. Among 34 monkeys, five capuchin monkeys (Sapajus spp.) and one marmoset (Callithrix spp.) showed Trypanosoma spp. sequences in the same clade of Trypanosoma minasense and three capuchin monkeys’ sequences were in the same clade of Trypanosoma cruzi. The Atlantic Forest and the Brazilian Amazon are the regions with the highest frequency of studies about Trypanosoma spp. and variety of Neotropical primate hosts. These are areas that deserve attention regarding the conservation of biodiversity, but it also makes evident the lack of studies with Neotropical primates in other regions of the country, as well as multidisciplinary studies to better understand the host pathogen relationships.

show abstract

Trypanosoma cruzi Infection in Non-Human Primates

Cited by 2 publications

References 37 publications

Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies

Pathologic characteristics of infectious diseases in macaque monkeys used in biomedical and toxicologic studies

Molecular detection and phylogenetic analysis of Trypanosoma spp. in Neotropical primates from Rio de Janeiro State, Brazil

Contact Info

Product

Resources

About