Trypanosoma cruzi: Effect of ethidium bromide on growth, dyskinetoplasty, and respiration of the Y and Costa Rica strains

H, Ucros; Leon, Wilson; Krassner, Stuart M.

doi:10.1016/0014-4894(77)90113-8

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1977

1986

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Cited by 8 publications

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“…2, 3 ) . A similar drop in oxygen uptake has been noted in other hemoflagellates rendered dyskinetoplastic by drugs (7,19). This suggests that thcse drugs adversely affcct mitochondria1 respiratory activity.…”

Section: Discussionsupporting

confidence: 70%

Effect of Berenil on Growth, Mitochondrial DNA and Respiration of Leishmania tarentolae Promastigotes*

Leon

Brun

Krassner

1977

The Journal of Protozoology

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Incubation of Leishmania tarentolae promastigotes in 1.0 microgram/ml Berenil for 96 hr resulted in approximately 33% inhibition of cell growth and approximately 42.5% dyskinetoplasty in the cell population. The buoyant density of kinetoplast DNA (kDNA), p = 1.703 g/ml, remained unchanged after 96-hr exposure to the drug. Endogenous respiration as well as proline- and glucose-induced respiration dropped markedly after 36-hr exposure to Berenil. This drop occurred approximately 12 hr before the onset of dyskinetoplasty, a result which suggests that this drug adversely affects mitochondrial respiratory activity of the promastigotes.

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Section: Discussionsupporting

confidence: 70%