Trypanosoma cruzi down-regulates adiponectin expression in mouse adipocytes via the NFAT signaling pathway

Santamaría, Miguel H.; Ríos, Luisa Delgado; Corral, Ricardo S.

doi:10.1016/j.micinf.2020.09.003

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…Furthermore, the expression of PPAR-y was also low. In the same mice model, it was found that the changes in lipid regulators were associated with calcium control, as the Ca2þ/calcineurin/NFAT cascade was upregulated in adipocytes, thus correlating with the decrease of adiponectin in adipocytes infected with T. cruzi [ 136 ].…”

Section: Adipocytes As Infection Targets and Their Relationship With ...mentioning

confidence: 99%

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

López‐Ortega

Moreno-Corona

Cruz-Holguin

et al. 2022

IJMS

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The current obesity pandemic has been expanding in both developing and developed countries. This suggests that the factors contributing to this condition need to be reconsidered since some new factors are arising as etiological causes of this disease. Moreover, recent clinical and experimental findings have shown an association between the progress of obesity and some infections, and the functions of adipose tissues, which involve cell metabolism and adipokine release, among others. Furthermore, it has recently been reported that adipocytes could either be reservoirs for these pathogens or play an active role in this process. In addition, there is abundant evidence indicating that during obesity, the immune system is exacerbated, suggesting an increased susceptibility of the patient to the development of several forms of illness or death. Thus, there could be a relationship between infection as a trigger for an increase in adipose cells and the impact on the metabolism that contributes to the development of obesity. In this review, we describe the findings concerning the role of adipose tissue as a mediator in the immune response as well as the possible role of adipocytes as infection targets, with both roles constituting a possible cause of obesity.

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Section: Adipocytes As Infection Targets and Their Relationship With ...mentioning

confidence: 99%

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

López‐Ortega

Moreno-Corona

Cruz-Holguin

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

et al. 2022

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Nuclear factor of activated T-cells, cytoplasmic 4 (NFATc4), a transcription factor of NFAT family, which is activated by Ca2+/calcineurin signaling. Recently, it is reported that aberrantly activated NFATc4 participated and modulated in the initiation, proliferation, invasion, and metastasis of various cancers (including cancers of the lung, breast, ovary, cervix, skin, liver, pancreas, as well as glioma, primary myelofibrosis and acute myelocytic leukemia). In this review, we cover the latest knowledge on NFATc4 expression pattern, post-translational modification, epigenetic regulation, transcriptional activity regulation and its downstream targets. Furthermore, we perform database analysis to reveal the prognostic value of NFATc4 in various cancers and discuss the current unexplored areas of NFATc4 research. All in all, the result from these studies strongly suggest that NFATc4 has the potential as a molecular therapeutic target in multiple human cancer types.

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Trypanosoma cruzi down-regulates adiponectin expression in mouse adipocytes via the NFAT signaling pathway

Cited by 2 publications

References 20 publications

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

Recent knowledge of NFATc4 in oncogenesis and cancer prognosis

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