Trypanosoma cruzi: Different methods of data analysis to evaluate the genetics–biology relationship

Lala, Eliane Raquel Peres; Andó, Míriam Hitomi; Zalloum, Leila; Bértoli, Marta; Dalalio, Márcia de Oliveira Machado; Silveira, Thaís Gomes Verzignassi; Gomes, Mônica Lúcia; Guedes, Terezinha Aparecida; Araújo, Silvana Márques de

doi:10.1016/j.exppara.2009.06.018

Cited by 2 publications

(1 citation statement)

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“…The parasitemia was more intense in iron-dextran-treated, mice and T. cruzi -specific IgG and IgM antibody levels were raised in the GN group but not in the conventional group [101, 102]. This study suggests that the effects of iron deficiency on T. cruzi infection are dependent on host background and T. cruzi strains , reinforcing the importance of the genetic diversity of parasites on the course of infection, as our group and others have previously demonstrated [103, 104]. …”

Section: Resultssupporting

confidence: 78%

Nutritional Status Driving Infection byTrypanosoma cruzi: Lessons from Experimental Animals

Malafaia

Talvani

2011

Journal of Tropical Medicine

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This paper reviews the scientific knowledge about protein-energy and micronutrient malnutrition in the context of Chagas disease, especially in experimental models. The search of articles was conducted using the electronic databases of SciELO (Scientific Electronic Library Online), PubMed and MEDLINE published between 1960 and March 2010. It was possible to verify that nutritional deficiencies (protein-energy malnutrition and micronutrient malnutrition) exert a direct effect on the infection by T. cruzi. However, little is known about the immunological mechanisms involved in the relationship “nutritional deficiencies and infection by T. cruzi”. A hundred years after the discovery of Chagas disease many aspects of this illness still require clarification, including the effects of nutritional deficiencies on immune and pathological mechanisms of T. cruzi infection.

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