Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya

Okello, Ivy; Mafie, Eliakunda; Nzalawahe, Jahashi; Eastwood, Gillian; Mboera, Leonard E. G.; Hakizimana, J.N.; Ogola, Kennedy

doi:10.1007/s11686-022-00640-3

Cited by 3 publications

(1 citation statement)

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“…Prevalence of trypanocide resistance is highly variable, and can be up to 100% as reported in T. congolense isolates from dogs in Nigeria ( Obi et al, 2022 ). However, a recent meta-analysis of 30 studies reported an overall prevalence of 29% for drug resistance in African animal trypanosomes ( Okello et al, 2022b ). A widespread incidence of trypanocide resistance was reported in the cotton belt of west Africa between eastern Guinea across southern Mali to the southwest of Burkina Faso, possibly linked to a high use of trypanocides ( Clausen et al, 2010 ; Grace et al, 2008 ).…”

Section: Epidemiology Of Veterinary Trypanocide Resistance: Incidence...mentioning

confidence: 99%

Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

Ungogo,

de Koning

2024

International Journal for Parasitology: Drugs and Drug Resistan

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Section: Epidemiology Of Veterinary Trypanocide Resistance: Incidence...mentioning

confidence: 99%

Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

Ungogo,

de Koning

2024

International Journal for Parasitology: Drugs and Drug Resistan

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Quality, supply chain, and use of Trypanocidal drugs among camel keepers in north-eastern Kenya: A cross-sectional study

Ogolla,

Mugunieri,

Mdachi

et al. 2024

Veterinary Parasitology: Regional Studies and Reports

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Trypanocide Use and Molecular Characterization of Trypanosomes Resistant to Diminazene Aceturate in Cattle in Northern Côte D’Ivoire

Ekra,

Mafie,

Sonan

et al. 2024

TropicalMed

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The resistance of trypanosomes to the doses of trypanocide administered by farmers to their animals acts as a real brake on efforts to control to combat African trypanosomiasis. Thus, in-depth knowledge of the use of these different molecules and their resistance profiles will be necessary to establish an integrated strategy to combat African trypanosomiasis. To achieve these objectives, a participatory survey among farmers and a resistance diagnosis of trypanosome strains identified in three regions of northern Côte d’Ivoire (Bagoué, Poro and Tchologo) was carried out using the PCR-RFLP technique, followed by sequencing of genes of interest. This study made it possible to identify three molecules that are commonly used by 85% (63/74) of farmers. In descending order of use, we identified Isometamidium chloride (43%), Diminazene aceturate (28%) and Homidium bromide (14%). Three species of trypanosomes, Trypanosoma congolense, Trypanosoma. theileri and Trypanosoma vivax, were identified in farms, and only one strain had the adenosine transporter gene (Trypanosoma congolense), but this strain was sensitive to the Diminazene aceturate molecule. Comparison of the sequence of this trypanosome strain showed that it is different to the Kenyan strain diagnosed as resistant to the Diminazene aceturate molecule. This study shows that a variety of trypanocides are used by farmers, and that the resistance profile of the strains to the Diminazene aceturate molecule could not be observed. However, it is important to further investigate the other molecules encountered in Côte d’Ivoire.

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Trypanosoma Congolense Resistant to Trypanocidal Drugs Homidium and Diminazene and their Molecular Characterization in Lambwe, Kenya

Cited by 3 publications

References 75 publications

Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

Drug resistance in animal trypanosomiases: Epidemiology, mechanisms and control strategies

Quality, supply chain, and use of Trypanocidal drugs among camel keepers in north-eastern Kenya: A cross-sectional study

Trypanocide Use and Molecular Characterization of Trypanosomes Resistant to Diminazene Aceturate in Cattle in Northern Côte D’Ivoire

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