Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania

Liu, Qin; Chen, Xiaoling; Chen, Mu-Xin; Xie, Hui; Liu, Qing; ZhuYun, Chen; Lin, Yao-Ying; Zheng, Hairong; Chen, Jiaxu; Zhang, Yi; Zhou, Xiao‐Nong

doi:10.1186/s40249-018-0432-5

Cited by 9 publications

(3 citation statements)

References 24 publications

(29 reference statements)

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“…3 (Liu et al, 2018) Africa (As shown in Table 2). It is supposed that the infection has been contracted in protected areas such as national parks (NP), wildlife reserves, and game reserves (Simarro et al, 2012;Selby et al, 2013).…”

Section: The Sources Of Imported Hat Cases In Non-endemic Regionsmentioning

confidence: 99%

Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases

et al. 2020

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Human African trypanosomiasis (HAT) is caused by Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense and caused devastating epidemics during the 20th century. Due to effective control programs implemented in the last two decades, the number of reported cases has fallen to a historically low level. Although fewer than 977 cases were reported in 2018 in endemic countries, HAT is still a public health problem in endemic regions until it is completely eliminated. In addition, almost 150 confirmed HAT cases were reported in non-endemic countries in the last three decades. The majority of non-endemic HAT cases were reported in Europe, USA and South Africa, due to historical alliances, economic links or geographic proximity to disease-endemic countries. Furthermore, with the implementation of the ‘Belt and Road’ project, sporadic imported HAT cases have been reported in China as a warning sign of tropical diseases prevention. In this paper, we explore and interpret the data on HAT incidence and find no positive correlation between the number of HAT cases from endemic and non-endemic countries. This data will provide useful information for better understanding the imported cases of HAT globally in the post-elimination phase.

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Section: The Sources Of Imported Hat Cases In Non-endemic Regionsmentioning

confidence: 99%

Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases

et al. 2020

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“…Experts from NIPD conducted investigations and timely testing allowing for the determination that the patient was the second imported case infected with Trypanosoma brucei. NIPD experts provided professional guidance for case treatment and follow-up, while also actively seeking the support from the World Health Organization to establish a drug reserve at NIPD for potential imported cases in future (Liu et al, 2018).…”

Section: Case Study V: Imported Africa Human Trypanosomiasismentioning

confidence: 99%

Construction and application of surveillance and response systems for parasitic diseases in China, led by NIPD-CTDR

Hao

Wang

Cao

et al. 2020

Advances in Parasitology

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Parasitic diseases have been widely epidemic in China with a long history. Great endeavours made in past 70 years led to significant decrease in morbidity and mortablity caused by several major parasitic diseases, while challenges existed to eliminate parasitic diseases. Surveillance-response system has play a crucial role in identifying public health problems, ascertaining the distribution and epidemic dynamics, discovering outbreaks and epidemic anomalies, evaluating the effects of on-site intervention activities and identifying risk factors. In this article, we reviewed the progress of the surveillance system for parasitic diseases, analysed the role of NIPD in the construction and application of surveillance-response system of parasitic diseases through elaborating the surveillance activities and typical surveillance-response events led by NIPD. Suggestion and comments for improve the surveillance-response system were put forward for further control or elimination of parasitic diseases.

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“…Furthermore, many areas are difficult to reach and the recorded cases could be underestimated. Meanwhile, the possibility of moving easily from and to Africa exposes an uncontrolled number of people to the infection [11][12][13]. In the last century, only four drugs were available for the treatment of HAT.…”

Section: Introductionmentioning

confidence: 99%

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

et al. 2022

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Human African Trypanosomiasis (HAT) is an endemic protozoan disease widespread in the sub-Saharan region that is caused by T. b. gambiense and T. b. rhodesiense. The development of molecules targeting rhodesain, the main cysteine protease of T. b. rhodesiense, has led to a panel of inhibitors endowed with micro/sub-micromolar activity towards the protozoa. However, whilst impressive binding affinity against rhodesain has been observed, the limited selectivity towards the target still remains a hard challenge for the development of antitrypanosomal agents. In this paper, we report the synthesis, biological evaluation, as well as docking studies of a series of reduced peptide bond pseudopeptide Michael acceptors (SPR10–SPR19) as potential anti-HAT agents. The new molecules show Ki values in the low-micro/sub-micromolar range against rhodesain, coupled with k2nd values between 1314 and 6950 M−1 min−1. With a few exceptions, an appreciable selectivity over human cathepsin L was observed. In in vitro assays against T. b. brucei cultures, SPR16 and SPR18 exhibited single-digit micromolar activity against the protozoa, comparable to those reported for very potent rhodesain inhibitors, while no significant cytotoxicity up to 70 µM towards mammalian cells was observed. The discrepancy between rhodesain inhibition and the antitrypanosomal effect could suggest additional mechanisms of action. The biological characterization of peptide inhibitor SPR34 highlights the essential role played by the reduced bond for the antitrypanosomal effect. Overall, this series of molecules could represent the starting point for further investigations of reduced peptide bond-containing analogs as potential anti-HAT agents

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Trypanosoma brucei rhodesiense infection in a Chinese traveler returning from the Serengeti National Park in Tanzania

Cited by 9 publications

References 24 publications

Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases

Human African trypanosomiasis: the current situation in endemic regions and the risks for non-endemic regions from imported cases

Construction and application of surveillance and response systems for parasitic diseases in China, led by NIPD-CTDR

Development of Reduced Peptide Bond Pseudopeptide Michael Acceptors for the Treatment of Human African Trypanosomiasis

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