Trypanoside, anti-tuberculosis, leishmanicidal, and cytotoxic activities of tetrahydrobenzothienopyrimidines

Pharmacologically potentials of hydrazonone containing compounds: a promising scaffold

“…Various hydrazones [11], [12] were act as selective inhibitors of S. aureus β-ketoacyl carrier proteinsynthase-3 . Aryloxyacetic acid hydrazide [13] having promising antibacterial activity against some bacterial strains (Abdel-Wahab et al, 2012). Cholic acid based hydrazones [14] showed antibacterial activity against Escherichia faecalis and E. coli (Rasras et al, 2010).…”

Synthesis of Potent Anticancer Thieno[2,3-d]Pyrimidine Derivatives

“…This observation was in accordance with the previously reported studies. 12,13 Among the 2-aryl-5,6,7,8,9,10-hexahydrocycloocta [4,5]thieno [2,3-d]pyrimidin-4(3H)-ones (8a-c) series, interestingly, 8c with C-2 thienyl substituent was the most active. Our interest was then focused on introducing substituents on C-4 to detect their effect on activity.…”

“…2). In order to explore the role of the cycloalkyl moiety in the potency of the anticancer activity, the hexahydrocycloocta ring was selected due to the fact that hexahydrocycloocta [4,5]thieno [2,3-d]pyrimidine was * Correspondent. E-mail: hanan-refaat@hotmail.com not previously screened as anticancer.…”

Synthesis, anticancer activity and effects on cell cycle profile and apoptosis of novel thieno[2,3-d]pyrimidine and thieno[3,2-e] triazolo[4,3-c]pyrimidine derivatives

“…In this study we are interested in the widely reported anticancer activity of thieno [2,3-d]pyrimidine derivatives via different mechanisms [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] and the presence of several potent marketed anticancer drugs such as gefitinib (Iressa TM ) [21] , erlotinib (Tarceva TM ) [22] and tandutinib Also, it was considered to synthesize several hexahydrocycloocta [4,5]thieno [3,2- …”