TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Shameer, Sanu; Logan-Klumpler, Flora J.; Vinson, Florence; Cottret, Ludovic; Merlet, Benjamin; Achcar, Fiona; Boshart, Michael; Berriman, Matthew; Breitling, Rainer; Bringaud, Frédéric; Bütikofer, Peter; Cattanach, Amy M.; Bannerman-Chukualim, Bridget; Creek, Darren J.; Crouch, Kathryn; Koning, Harry P. de; Denise, Hubert; Ebikeme, Charles; Fairlamb, Alan H.; Ferguson, Michael A. J.; Ginger, Michael L.; Hertz‐Fowler, Christiane; Kerkhoven, Eduard J.; Mäser, Pascal; Michels, Paul A.M.; Nayak, Archana; Nes, David W.; Nolan, Derek P.; Olsen, Christian A.; Silva-Franco, Fatima; Smith, Terry; Taylor, Martin C.; Tielens, Aloysius G.M.; Urbaniak, Michael D.; Hellemond, Jaap J. van; Vincent, Isabel M.; Wilkinson, Shane R.; Wyllie, Susan; Opperdoes, Frederik; Barrett, Michael P.; Jourdan, Fabien

doi:10.1093/nar/gku944

Cited by 33 publications

(33 citation statements)

References 45 publications

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“…Lister 427) are well adapted to laboratory in vitro culture and have been used as model organism to study many eukaryotic cell processes. The genome of this species was published in 2005 (Berriman et al 2005) and its metabolism has been widely studied (Shameer et al 2015). It has long been known that, in its bloodstream form, T. brucei species depend entirely on glycolysis for energy production, while Krebs cycle and oxidative phosphorylation are active only in the insect stages.…”

Section: Animal Trypanosome Species: Virulence Tissue Distibution Bmentioning

confidence: 99%

The animal trypanosomiases and their chemotherapy: a review

et al. 2016

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SUMMARYPathogenic animal trypanosomes affecting livestock have represented a major constraint to agricultural development in Africa for centuries, and their negative economic impact is increasing in South America and Asia. Chemotherapy and chemoprophylaxis represent the main means of control. However, research into new trypanocides has remained inadequate for decades, leading to a situation where the few compounds available are losing efficacy due to the emergence of drug-resistant parasites. In this review, we provide a comprehensive overview of the current options available for the treatment and prophylaxis of the animal trypanosomiases, with a special focus on the problem of resistance. The key issues surrounding the main economically important animal trypanosome species and the diseases they cause are also presented. As new investment becomes available to develop improved tools to control the animal trypanosomiases, we stress that efforts should be directed towards a better understanding of the biology of the relevant parasite species and strains, to identify new drug targets and interrogate resistance mechanisms.

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Section: Animal Trypanosome Species: Virulence Tissue Distibution Bmentioning

confidence: 99%

The animal trypanosomiases and their chemotherapy: a review

et al. 2016

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“…alpha-ketoglutarate indicates the preferential use of the glycosomal metabolic pathways for energy production due to the consumption of succinate to produce pyruvate in the epimastigotes of T. cruzi [7,21].…”

Section: Discussionmentioning

confidence: 99%

Benznidazole induces in vitro anaerobic metabolism in Trypanosoma cruzi epimastigotes

Vinaud¹,

Nogueira²,

Fraga³

et al. 2017

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“…Metabolic pathways. Pathways are integrated from Meta-Cyc, KEGG, TrypanoCyc and LeishCyc (18)(19)(20)(21)(22) as networks of enzymatic reactions and substrate/product compounds. Genes are mapped to Pathways based on EC numbers.…”

Section: Genome Sequence Annotation and Functional Genomics Datamentioning

confidence: 99%

EuPathDB: the eukaryotic pathogen genomics database resource

et al. 2016

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The Eukaryotic Pathogen Genomics Database Resource (EuPathDB, http://eupathdb.org) is a collection of databases covering 170+ eukaryotic pathogens (protists & fungi), along with relevant free-living and non-pathogenic species, and select pathogen hosts. To facilitate the discovery of meaningful biological relationships, the databases couple preconfigured searches with visualization and analysis tools for comprehensive data mining via intuitive graphical interfaces and APIs. All data are analyzed with the same workflows, including creation of gene orthology profiles, so data are easily compared across data sets, data types and organisms. EuPathDB is updated with numerous new analysis tools, features, data sets and data types. New tools include GO, metabolic pathway and word enrichment analyses plus an online workspace for analysis of personal, non-public, large-scale data. Expanded data content is mostly genomic and functional genomic data while new data types include protein microarray, metabolic pathways, compounds, quantitative proteomics, copy number variation, and polysomal transcriptomics. New features include consistent categorization of searches, data sets and genome browser tracks; redesigned gene pages; effective integration of alternative transcripts; and a EuPathDB Galaxy instance for private analyses of a user's data. Forthcoming upgrades include user workspaces for private integration of data with existing EuPathDB data and improved integration and presentation of host–pathogen interactions.

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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei

Cited by 33 publications

References 45 publications

The animal trypanosomiases and their chemotherapy: a review

The animal trypanosomiases and their chemotherapy: a review

Benznidazole induces in vitro anaerobic metabolism in Trypanosoma cruzi epimastigotes

EuPathDB: the eukaryotic pathogen genomics database resource

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