Trypanocidal Diarylheptanoids from <i>Aframomum letestuianum</i>

Kamnaing, Pierre; Tsopmo, Apollinaire; Tanifum, Eric A.; Tchuendem, Marguerite Hortence K.; Tané, Pierre; Ayafor, J. Foyere; Sterner, Olov; Rattendi, Donna; Iwu, Maurice M.; Schuster, Brian G.; Bacchi, Cyrus J.

doi:10.1021/np020362f

Cited by 36 publications

(13 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This plant is a potential source of a new antimalarial drug. The genus Aframomum includes several species with strong antiplasmodial activity (Duker-Eshun et al, 2002;Kenmogne et al, 2006) mediated by flavonoids, diaryl heptanoids and sesquiterpenes (De Bernardi et al, 1981;Kamnaing et al, 2003). Our results are consistent with the use of this plant for traditional medicine in Haut-Ogooué.…”

Section: Aframomum Giganteumsupporting

confidence: 89%

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Lékana-Douki

Bongui

Liabagui

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Section: Aframomum Giganteumsupporting

confidence: 89%

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Lékana-Douki

Bongui

Liabagui

et al. 2011

Journal of Ethnopharmacology

View full text Add to dashboard Cite

“…Sceptrumlabdalactone B (52, Figure 9) was identified, from the rhizomes of A. sceptrum, a plant locally used for the treatment of infectious diseases including human African trypanosomiasis (sleeping sickness), together with sceptrumlabdalactone A. [127][128][129][130] The activity of compound 52 (with IC50 value of 5.7 μM) against L. donovani was comparable to that of reference drugs (IC50 of 2.5 and 3.0 μM for pentamidine and miltefosine respectively). Additionally, this molecule demonstrated selective activity for L. donovani, when compared with the activity against T. b. brucei.…”

Section: Diterpenoidsmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

View full text Add to dashboard Cite

An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

show abstract

“…It should be noted that the additional methoxy group in 74 compared to 73 renders it inactive. 59 Two arylnaphthalide lignans were isolated from the aerial parts of Phyllanthus piscatorum (Euphorbiaceae): justicidin B 76 and its C 11 -hydroxylated derivative, piscatorin 77. Compound 76 exhibited a strong activity against the bloodstream trypomastigotes of T. b. rhodesiense (IC 50 = 0.55 µM) while 77 was 11 times less active (IC 50 = 6.1 µM).…”

Section: 52mentioning

confidence: 99%

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

et al. 2004

View full text Add to dashboard Cite

This review covers compounds with activity on African trypanosomes (mainly Trypanosoma brucei subsp., T. congolense and T. vivax) isolated from natural sources and is organized according to the structure of the metabolites (alkaloids, phenolic derivatives, quinones, terpenes and other metabolites). The literature from the mid-1980s up to June 2003 is reviewed and 89 references are cited. Sara Hoet was born in

show abstract

Trypanocidal Diarylheptanoids from Aframomum letestuianum

Cited by 36 publications

References 12 publications

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Natural Products Active Against African Trypanosomes: A Step Towards New Drugs

Contact Info

Product

Resources

About