Trying to overcome the ‘chicken or egg’ impasse in bicuspid aortopathy research

Corte, Alessandro Della

doi:10.1093/ejcts/ezv173

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…However, it is unclear whether the associated findings are a consequence of the dilatation itself rather than a determinant or risk factor. 256 Future research must advance beyond associative studies toward more informative mechanistic investigations, functional studies, and experimental validations. Clinical randomized trials, particularly of pharmacologic treatments to slow the progression of aortic dilatation or prevent acute events, are particularly warranted.…”

Section: Knowledge Gaps and Future Researchmentioning

confidence: 99%

The American Association for Thoracic Surgery consensus guidelines on bicuspid aortic valve–related aortopathy: Full online-only version

Borger

Fedak

Stephens

et al. 2018

The Journal of Thoracic and Cardiovascular Surgery

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218

185

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Bicuspid aortic valve disease is the most common congenital cardiac disorder, being present in 1% to 2% of the general population. Associated aortopathy is a common finding in patients with bicuspid aortic valve disease, with thoracic aortic dilation noted in approximately 40% of patients in referral centers. Several previous consensus statements and guidelines have addressed the management of bicuspid aortic valve-associated aortopathy, but none focused entirely on this disease process. The current guidelines cover all major aspects of bicuspid aortic valve aortopathy, including natural history, phenotypic expression, histology and molecular pathomechanisms, imaging, indications for surgery, surveillance, and follow-up, and recommendations for future research. It is intended to provide clinicians with a current and comprehensive review of bicuspid aortic valve aortopathy and to guide the daily management of these complex patients.

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Section: Knowledge Gaps and Future Researchmentioning

confidence: 99%