Trustworthiness before Trust — Covid-19 Vaccine Trials and the Black Community

Warren, Ricks; Forrow, Lachlan; Hodge, David Augustin; Truog, Robert D.

doi:10.1056/nejmp2030033

Cited by 190 publications

(181 citation statements)

References 1 publication

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“…Persistent issues of trust in the modern medical system among these groups speaks to a larger trend in perceptions of healthcare among minority groups in the U.S., which may drive individuals to seek alternative or complimentary medicine, or to neglect health concerns altogether. 19-21 This trust gap, which stems in part from long-term issues of systemic biases in health research and healthcare delivery 22,23 , will have important implications for the adoption and roll-out of a novel coronavirus vaccine.…”

Section: Discussionmentioning

confidence: 99%

Assessment of COVID-19 vaccine acceptance among healthcare workers in Los Angeles

Gadoth

Halbrook

Martin-Blais

et al. 2020

Preprint

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ImportanceHealthcare workers (HCW) are slated to be early recipients of SARS-CoV-2 vaccines due to increased risk of exposure to patients with COVID-19, and will be tasked with administering approved vaccines to the general population. As lynchpins of the vaccination effort, HCWs’ opinions of a vaccine’s safety and efficacy may affect both public perception and uptake of the vaccine. Therefore, it is crucial to understand and address potential hesitancy prior to vaccine administration.ObjectiveTo understand healthcare workers’ attitudes about vaccine safety, efficacy, and acceptability in the context of the COVID-19 pandemic, including acceptance of a novel coronavirus vaccine.Design, Setting, ParticipantsA cross-sectional survey was distributed to participants enrolled in a longitudinal cohort study surveilling SARS-CoV-2 infection among 1,093 volunteer sampled University of California, Los Angeles (UCLA) Health System employees. Surveys were completed online between September 24 and October 16, 2020. In total, 609 participants completed this supplemental survey.ResultsWe averaged a 9-statement Likert scale matrix scored from 1 (“strongly disagree”) to 5 (“strongly agree”) and found respondents overwhelmingly confident about vaccine safety (4.47); effectiveness (4.44); importance, self-protection, and community health (4.67). Notably, 47.3% of respondents reported unwillingness to participate in a coronavirus vaccine trial, and most (66.5%) intend to delay vaccination. The odds of reporting intent to delay coronavirus vaccine uptake were 4.15 times higher among nurses, 2.45 times higher among other personnel with patient contact roles, and 2.15 times higher among those without patient contact compared to doctors. Evolving SARS-CoV-2 science (76.0%), current political climate (57.6%), and fast-tracked vaccine development timeline (83.4%) were cited as primary variables impacting HCW decisions to undergo vaccination. Of note, these results were obtained prior to release of Phase III data from companies manufacturing vaccines in the U.S.Conclusions and RelevanceDespite overall confidence in vaccines, a majority of HCW expressed concerns over a novel coronavirus vaccine. A large proportion plan to delay vaccine uptake due to concerns about expedited development, emerging scientific discoveries, and the political climate. Forthcoming vaccination campaigns must address these unique points of coronavirus vaccine hesitancy in order to achieve adequate vaccine coverage.

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Section: Discussionmentioning

confidence: 99%

Assessment of COVID-19 vaccine acceptance among healthcare workers in Los Angeles

Gadoth

Halbrook

Martin-Blais

et al. 2020

Preprint

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“…Finally, as a major constituent of the cultural and political "system," healthcare must figure out how to become trustworthy and anti-racist in the face of the systemic racism laid bare in the time of COVID-19. 78,79 Examining privilege and power are necessary within healthcare and among its practitioners.…”

Section: Conclusion: Next Stepsmentioning

confidence: 99%

Witnesses and Victims Both: Healthcare Workers and Grief in the Time of COVID-19

Rabow

Huang

White-Hammond

et al. 2021

Journal of Pain and Symptom Management

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…Researchers should then explain the plans for their trial going forward and solicit participants' consent. To minimize potential confusion and distrust (14), participants should understand the rationale behind the plan and that their prior consent does not obligate them to continue to participate. If researchers intend to continue with a placebo-controlled design, participants can be encouraged to remain in the trial.…”

Section: Disclosure Unblinding Consentmentioning

confidence: 99%