Due to incredible advancements in the processes of manufacturing, the world is facing a fourth industrial revolution focusing on the development of cyber-physical systems. Human-robot collaboration will be an integral part of these new systems. In the conventional manufacturing process humans and robots have been kept separate from each other to prevent serious harm coming to the human operators. However, considerable advancements in technology have introduced large-scale robotics that are able to successfully and safely interact with human workers, which we will soon see being deployed across the manufacturing industry, to work alongside teams of human operators to improve many aspects of the production process such as speed and uniformity. These developments will not only revolutionise the processes of manufacturing, but will also have a considerable impact on the humans that will be working alongside them. These changes could have physical, mental and emotional impacts on human operators who will likely experience considerable changes to the way they work. In this paper we will discuss the current challenges facing human-robot collaboration integration, worker needs, acceptance, trust, and other ethical issues concerning what changes may need to be made for the successful integration of collaborative robotics, and how this research will identify the human factors that need to be incorporated within future risk assessments/systems integration.