Truncations and in silico Docking to Enhance the Analytical Response of Aptamer-Based Biosensors
Minh-Dat Nguyen,
Meghan Osborne,
Guy Terence Prevot
et al.
Abstract:Aptamers are short oligonucleotides capable of binding specifically to various targets (i.e., small molecules, proteins, and whole cells) which have been introduced in biosensors such as in the electrochemical aptamer-based (E-AB) sensing platform. E-AB sensors are comprised of a redox-reporter-modified aptamer attached to an electrode that undergoes, upon target addition, a binding-induced change in electron transfer rates. To date, E-AB sensors have faced a limitation in the translatability of aptamers into … Show more
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