True Boiling Point Extended Curve of Vacuum Residue Through Molecular Distillation

Copaifera is a tree that produces an oleoresin that has great historical and economic importance. These oleoresins display several pharmacological properties, such as antiinflammatory and antimicrobial, among others. The commercialization of Copaifera oleoresin occurs, in many cases, without any quality control, which facilitates its adulteration. Validated analytical methods can provide a safe quality control. In this work, the 800 Automatic Spinning Band Distillation equipment was used to perform the fractionation of the volatile oils obtained by hydrodistillation of Copaifera multijuga, C. paupera, C. Publifora and C. langsdorffii, aiming to isolate and purify the major compounds present in these oils. For purification, classical column chromatography was used, furnishing six isolated sesquiterpenes. The sesquiterpenes were used as standards in the development and validation of the method by GC-FID. The evaluated parameters were selectivity, linearity, precision, accuracy and robustness and they are all in accordance with ANVISA and International Conference on Harmonization guidelines. The developed method is reliable for the quantification of sesquiterpenes in Copaifera oleoresins. Both volatile oils and isolated sesquiterpenes had their minimum inhibitory concentration determined against strains of Gram-negative and Grampositive bacteria and yeasts. Copaifera langsdorffi oleoresin was the only one active against all of the evaluated microorganisms, displaying good antimicrobial potential.

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“…Each fraction was collected according to the atmospheric equivalent temperature (AET). Sbaite et al () reported the equation for AET:

AET = \frac{748.1 \times A}{\frac{1}{T} + 0.3861 \times A - 0.00051606} - 271.1 .

where AET is in °C, A is the value obtained from equation (2) and T is the experimental temperature (K).

A = \frac{5.9991972 - ((), 0.9774472 \times log P)}{2663.129 - ((), 95.76 \times log P)}

where P is experimental system pressure (mmHg).…”

Section: Methodsmentioning

confidence: 99%

Use of spinning band distillation equipment for fractionation of volatile compounds ofCopaiferaoleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity

Ribeiro

Arruda

Silva

et al. 2018

Biomedical Chromatography

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“…The technique is based upon short path distillation in high vacuum conditions (0.1 Pa), which represents a smaller operational temperature and a smaller exposure time of the distilled liquid on the heated surface. In addition, research carried out and in progress at LDPS/LOPCA/UNICAMP-Petrobras Sbaite et al, 2006;Zuñiga Liñan et al, 2010) has demonstrated the TBP curves can be extended above 838.15 K, which represents a gain of over 70-80% in mass of the petroleum residue yield, compared with the 30-60% in mass obtained by conventional methods. The molecular distillation of petroleum residues is a complex process characterized by nonlinear dynamic and space-varying behavior.…”

Section: Introductionmentioning

confidence: 94%

Fuzzy cognitive approach of a molecular distillation process

Lima

Liñan

Manenti

et al. 2011

Chemical Engineering Research and Design

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“…This process has been applied to lipid-containing products, including monoglycerides production (12), recovery of carotenoids from palm oil (13), and purification of structured lipids (14). Also, it can be applied to fuel product, like production of biodiesel from castor oil (15) and heavy petroleum characterization (16). Ito et al (17) studied the recovery of tocopherols and FFAs from SODD in function of the ratio (distillate flow rate [D]/residue flow rate [R]) of 0.96, and the tocopherol and FFA recovery curves had an optimum point at 73%.…”

Section: Introductionmentioning

confidence: 99%

Optimization of tocopherol concentration process from soybean oil deodorized distillate using response surface methodology

Ito

Batistella

Maciel

et al. 2007

Appl Biochem Biotechnol

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Soybean oil deodorized distillate is a product derived from the refining process and it is rich in high value-added products. The recovery of these unsaponifiable fractions is of great commercial interest, because of the fact that in many cases, the "valuable products" have vitamin activities such as tocopherols (vitamin E), as well as anticarcinogenic properties such as sterols. Molecular distillation has large potential to be used in order to concentrate tocopherols, as it uses very low temperatures owing to the high vacuum and short operating time for separation, and also, it does not use solvents. Then, it can be used to separate and to purify thermosensitive material such as vitamins. In this work, the molecular distillation process was applied for tocopherol concentration, and the response surface methodology was used to optimize free fatty acids (FFA) elimination and tocopherol concentration in the residue and in the distillate streams, both of which are the products of the molecular distiller. The independent variables studied were feed flow rate (F) and evaporator temperature (T) because they are the very important process variables according to previous experience. The experimental range was 4-12 mL/min for F and 130-200 degrees C for T. It can be noted that feed flow rate and evaporator temperature are important operating variables in the FFA elimination. For decreasing the loss of FFA, in the residue stream, the operating range should be changed, increasing the evaporator temperature and decreasing the feed flow rate; D/F ratio increases, increasing evaporator temperature and decreasing feed flow rate. High concentration of tocopherols was obtained in the residue stream at low values of feed flow rate and high evaporator temperature. These results were obtained through experimental results based on experimental design.

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True Boiling Point Extended Curve of Vacuum Residue Through Molecular Distillation

Cited by 24 publications

References 8 publications

Use of spinning band distillation equipment for fractionation of volatile compounds ofCopaiferaoleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity

Use of spinning band distillation equipment for fractionation of volatile compounds ofCopaiferaoleoresins for developing a validated gas chromatographic method and evaluating antimicrobial activity

Fuzzy cognitive approach of a molecular distillation process

Optimization of tocopherol concentration process from soybean oil deodorized distillate using response surface methodology

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