True and pseudo cholinesterases in depression

Mathew, Roy J.; Ho, Beng T.; Khan, Mohammad Ayub; Perales, Carmen Sánchez; Weinman, Maxine L.; Claghorn, James L.

doi:10.1176/ajp.139.1.125

Cited by 20 publications

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“…3 Correlations have been reported between some psychiatric disorders, such as major depression, severe anxiety disorder, and obsessive-compulsive disorder (OCD) and increased PChE activity. 6 - 8 The aim of our study was to retrospectively assess the correlations between PChE levels and age, gender, body weight and diagnosed psychiatric diseases in ECT cases receiving anesthesia at the third-stage Educational Hospital in Zonguldak province in the northwest region of Turkey.…”

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confidence: 99%

Pseudocholinesterase levels in patients under electroconvulsive therapy

Küçükosman

Pişkin

Hancı

et al. 2018

SMJ

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Objectives:In this study, we aimed to retrospectively assess the correlation of pseudocholinesterase (PChE) levels with age, gender, body weight and diagnosed psychiatric diseases in electroconvulsive therapy (ECT) cases.Methods:This retrospective study was conducted at Bülent Ecevit University Hospital, Zonguldak, Turkey, between 2007 and 2011. In the study, 193 ECT case files were retrospectively scanned to evaluate PChE values before ECT and other file information.Results:There was no difference between gender in terms of PChE levels. Correlation analysis determined a weakly positive correlation between age (p=0.013; correlation coefficient [cc]: 0.178) and body weight (p<0.001; cc: 0.273) and PChE levels. No correlation was found between age, gender, weight or psychiatric diagnosis, and PChE levels.Conclusion:Neuromuscular blockage is a significant factor that increases patient safety, while increasing the efficacy of ECT. In choosing muscle relaxant agents, both patient factors and the pharmacological properties of the neuromuscular blocker should be considered. We think that in situations with delayed recovery of ECT cases without identified PChE levels, low PChE levels must be considered.

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mentioning

confidence: 99%

Pseudocholinesterase levels in patients under electroconvulsive therapy

Küçükosman

Pişkin

Hancı

et al. 2018

SMJ

View full text Add to dashboard Cite

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References

2010

Biological Psychiatry

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Plasma cholinesterase activities in dementias, depressions and schizophrenia

Chipperfield¹,

Smith²,

Moyes³

1987

Int J Geriat Psychiatry

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SUMMARYPlasma cholinesterase activities were measured in a group of elderly patients and controls. Total cholinesterase activity was found to be decreased to a just significant extent in those suffering from endogenous depression when compared to normal controls. There was a highly significant decrease in cholinesterase activity in the plasma of patients suffering from senile dementia of Alzheimer type (SDAT) but not in those suffering from multi-infarct dementia, neurotic depression or chronic schizophrenia. There was a just significant correlation between total cholinesterase and acetylcholinesterase activity in the plasma of patients suffering from SDAT and the degree of dementia. There were also significant differences between patients with S D A T and MID, and patients with endogenous and reactive depression. The potential use of such tests is discussed.KEY WORDS-ChOlineSteraSeS, senile dementia, SDAT, multi-infarct dementia MID, depressive disorder, schizophrenia.

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True and pseudo cholinesterases in depression

Cited by 20 publications

References 0 publications

Pseudocholinesterase levels in patients under electroconvulsive therapy

Pseudocholinesterase levels in patients under electroconvulsive therapy

References

Plasma cholinesterase activities in dementias, depressions and schizophrenia

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