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doi:10.1038/sj/leu/2401491

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Cited by 5 publications

References 13 publications

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The health benefits of vitamin K

2015

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Vitamin K has important functions within the body, some of which are still being discovered. Research has shown that vitamin K is an anticalcification, anticancer, bone-forming and insulin-sensitising molecule. Recent data indicate that subclinical vitamin K deficiency is not uncommon. Additionally, vitamin K antagonists such as warfarin may cause detrimental side effects, which may partly be blunted through vitamin K supplementation.

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The health benefits of vitamin K

2015

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Vitamins In Hepatocellular Carcinoma

Tamori¹,

Shiomi²

2009

Nutrition, Diet Therapy, and the Liver

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Antiproliferative and Apoptosis-Inducing Effects of Lipophilic Vitamins on Human Melanoma A375 Cells in Vitro

Ishibashi

Arai

Tanaka

et al. 2012

Biological & Pharmaceutical Bulletin

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The effects of six lipophilic vitamins: tretinoin (ATRA), vitamin D(3) (VD(3)), VE, VK(1), VK(3), and VK(5) on cell proliferation and apoptosis in human A375 melanoma cells were investigated. VD(3), VK(3), and VK(5) were found to inhibit cell proliferation significantly at concentration ranges of 10-100 μmol/L (p<0.01), while the other vitamins did not show inhibitory effects at 100 μmol/L. VK(3) and VK(5) showed the strongest effects with IC(50) values of less than 10 μmol/L. Dacarbazine slightly inhibited the proliferation of A375 cells at a concentration range of 25-100 μmol/L, but the effects were not statistically significant. VK(3) and VK(5) increased annexin-V positive apoptotic cells, as well as activating caspase-3, in A375 cells. Our findings showed that VD(3), VK(3,) and VK(5) inhibited the growth of dacarbazine resistant human melanoma cells, while ATRA, VE, and VK(1) had little effect on the cell growth. The effects of VK(3) and VK(5) were observed at concentrations lower than 10 μmol/L, which are suggested to have resulted from apoptosis-induction in the melanoma cells.

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Abstract: We have previously reported that vitamin K 2 (VK2) has a potent apoptosis inducing activity toward various types of primary cultured leukemia cells including acute myelogenous leukemia arising from myelodysplastic syndromes (MDS). We estab-

Cited by 5 publications

References 13 publications

The health benefits of vitamin K

The health benefits of vitamin K

Vitamins In Hepatocellular Carcinoma

Antiproliferative and Apoptosis-Inducing Effects of Lipophilic Vitamins on Human Melanoma A375 Cells in Vitro

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