TRPV6 plays a new role in predicting survival of patients with esophageal squamous cell carcinoma

Abstract

BackgroundTRPV6 is over-expressed and promotes the proliferation and invasion in many cancers. The association between the expression of TRPV6 and clinical outcome in esophageal squamous cell carcinoma (ESCC) has not been studied yet. We aim to elucidate the role of TRPV6 in predicting prognosis of patients with ESCC.MethodsIn the retrospective study, mRNA level of TRPV6 was examined in patients (N = 174) from Sun Yat-sen University Cancer Center (mRNA cohort) and protein level of TRPV6 was examined in patients (N = 218) from Linzhou Cancer Hospital (protein cohort). Statistical analysis was performed to test the clinical and prognostic significance of TRPV6.ResultsTRPV6 was down-regulated in ESCC tissues and cell lines. Patients with downregulation of TRPV6 trended to have a higher rate of advanced pT stage in both mRNA cohort (P = 0.089) and protein cohort (P = 0.073), though not statistically significant. No significant association was observed between TRPV6 expression and disease-specific survival (DSS) in both two cohorts. However, stratified survival analysis based on the gender showed that in mRNA cohort, downregulation of TRPV6 was associated with an unfavorable 3-year DSS in patients with male (47.3 % vs 63.6 %, P = 0.027) and with favorable 3-year DSS in patients with female (66.7 % vs 43.0 %, P = 0.031). The result was confirmed in protein cohort. Male patients with downregulation of TRPV6 had a poor 3-year DSS (20.0 % vs 57.1 %,P < 0.001) while female counterparts showed an enhanced 3-year DSS (56.1 % vs 28.6 %, P = 0.005).ConclusionTRPV6 is down-regulated in ESCC. As a predictive biomarker, TRPV6 plays a Janus-like role in predicting survival of male and female ESCC patients.

Expression and prognostic significance of TRPV6 in the development and progression of pancreatic cancer

“…The TRPV6 channel is a calcium cation channel protein, which is the major constituent of superfamily of transient receptor potential (TRP) channels, further in terms of subfamily vanilloid member 6, which regulates the calcium homeostasis in the epithelial tissue of human organs (3). TRPV6 is overexpressed in colon cancer, breast cancer, prostate cancer, parathyroid cancer and thyroid cancer (3)(4)(5)(6), however decreased TRPV6 expression was observed in esophageal cancer, non-small cell lung cancer and renal cancer (7)(8)(9). Overexpression of TPPV6 in many cancers indicates the idea of this protein as encoded by a probable oncogene, but the level of TRPV6 in other cancers showed a tendency of a tumor-suppressor.…”

Elevated pretreatment serum lactate dehydrogenase level predicts inferior overall survival and disease-free survival after resection of thymic carcinoma

“…internal anaerobic metabolism of cancer cells is highly activated (34), therefore, LDH acts as a biomarker for tumor burden, and reflects tumor progression and tumor burden (35). In resent, several studies on cancer related elevation of LDH have been reported, and prognostic significance of serum LDH has been verified (21,31,(35)(36)(37)(38). Similarly, in this study on the prognostic role of LDH in TC, we found that the elevated pretreatment serum LDH level was associated with poor OS and short DFS after resection of TC.…”

“…LDH is abundant in some organs, such as heart, liver, kidney and muscle. When these organs are affected by malignancies, inflammation and toxicity, LDH releases from the cracked cell, which finally results in the elevation of serum LDH level (31,32). Rapid progression of malignancies leads to low-oxygen conditions in tumor microenvironment (33), for adapting to these conditions, CT + S + CRT 1 (1.7)…”

Overexpression of sperm associated antigen 5 promotes cell growth, metastasis, and adriamycin resistance in esophageal squamous cell carcinoma via activating PI3K/AKT signaling pathway

“…Esophageal cancer (ESCC) is a kind of malignant tumor of digestive system which occurs in esophageal epithelial tissue [1]. The histopathological types of esophageal cancer can be divided into two types, one is ESCC [2], the other is esophageal adenocarcinoma [3]. China has a high incidence of ESCC [4].…”