TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System

Amalia, Syahla Nisaa; Baral, Hritu; Fujiwara, Chisako; Uchiyama, Akihiko; Inoue, Yuta; Yamazaki, Sunao; Ishikawa, M.; Kosaka, Keiji; Sekiguchi, Akiko; Yokoyama, Yoko; Ogino, Sachiko; Torii, Ryoko; Hosoi, Mari; Shibasaki, Kazuo; Motegi, Sei‐ichiro

doi:10.1016/j.jid.2023.05.009

Cited by 5 publications

(4 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies on imiquimod-induced psoriasis have revealed that macrophage infiltration in the skin can be reduced by genetic knockdown of the gene encoding the transient receptor potential cation channel subfamily V member 4 (TRPV4) calcium ion channel [132] as well as by orally administered resveratrol [133]. Analogously, at present, skin-infiltrating monocytes have gained researchers' attention as possible therapeutic targets to prevent their in situ differentiation into inflammatory macrophages or dendritic cells [134].…”

Section: Therapeutic Targeting Of Macrophage-dependent Cytokine and M...mentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

View full text Add to dashboard Cite

Psoriasis is a systemic autoimmune/autoinflammatory disease that can be well studied in established mouse models. Skin-resident macrophages are classified into epidermal Langerhans cells and dermal macrophages and are involved in innate immunity, orchestration of adaptive immunity, and maintenance of tissue homeostasis due to their ability to constantly shift their phenotype and adapt to the current microenvironment. Consequently, both macrophage populations play dual roles in psoriasis. In some circumstances, pro-inflammatory activated macrophages and Langerhans cells trigger psoriatic inflammation, while in other cases their anti-inflammatory stimulation results in amelioration of the disease. These features make macrophages interesting candidates for modern therapeutic strategies. Owing to the significant progress in knowledge, our review article summarizes current achievements and indicates future research directions to better understand the function of macrophages in psoriasis.

show abstract

Section: Therapeutic Targeting Of Macrophage-dependent Cytokine and M...mentioning

confidence: 99%

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Nazimek,

Bryniarski

2024

IJMS

View full text Add to dashboard Cite

show abstract

“…In mouse models of chemically induced psoriasis, Trpv4-knockout mice exhibited milder dermatitis than wild-type mice. TRPV4 was found to be essential for mediating the expression of adenosine triphosphate derived from keratinocytes to activate and amplify immune responses [ 31 ]. Moreover, the expression levels of TRPV4 in the skin of three patients correlated positively with the severity of their psoriasis, and psoriasis-induced itch is strongly associated with TRPV4 activation [ 31 ].…”

Section: Ion Channels In Keratinocytesmentioning

confidence: 99%

Section: Type Of Ion Channels Expression Change In Psoriasis Mutationmentioning

confidence: 99%

“…nAChR α5 ↑ in keratinocytes [11] α7 ↑ in keratinocytes [4] ↑ in immune cells [23] TRPA1 ↑ in keratinocytes [26] TRPV1 ↑ in keratinocytes [14] no change in keratinocytes [26] ↑ in immune cells [27] TRPV3 ↑ in keratinocytes [28] ↓ in immune cells [27] R416Q, R416W, L655P, W692S, L694P, G568D, G568V, L673F: ion channel activity ↑ severe Olmsted syndrome (L673F, W692S) mild Olmsted syndrome variants (R416Q) [29] G573A [30] TRPV4 ↑ in keratinocytes [31] ↓ in immune cells [27] ↑ in neurons [32] TRPM TRPM2 ↑ TRPM4, M7 ↓ in immune cells [27] TRPM8 ↓ in neurons [32] I1033M, I1040T (human): ion channel activity ↑ [33] I1029M (mouse): ion channel activity ↑ [34] TRPC TRPC1,3,4,5,6,7 ↓ in keratinocytes [35] TRPC6 ↓ in immune cells [27] CaSR ↓ in epidermis [36] STIM/ORAI ↓ in epidermis [36] ANO1 ↑ in keratinocytes [9] Nav Nav1.8 ↑ in keratinocytes [37] Polycystin PC1 ↓ in keratinocytes [38] Kv Kv1.3 ↑ in epidermis [39,40] KCa Kca3.1 ↑ in epidermis [21]…”

Section: Type Of Ion Channels Expression Change In Psoriasis Mutationmentioning

confidence: 99%

See 1 more Smart Citation

Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis

Kim,

Choi,

Jeon

et al. 2024

IJMS

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of skin cells in the epidermis, driven by an overactive immune system. Consequently, a complex interplay among epidermal cells, immune cells, and sensory neurons contributes to the development and progression of psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP channels, Ca2+ release-activated channels, chloride channels, and potassium channels, each serve specific functions to maintain the homeostasis of the skin. The dysregulation of ion channels plays a major role in the pathophysiology of psoriasis, affecting various aspects of epidermal cells, immune responses, and sensory neuron signaling. Impaired function of ion channels can lead to altered calcium signaling, inflammation, proliferation, and sensory signaling, all of which are central features of psoriasis. This overview summarizes the pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons during early and late psoriatic processes, thereby contributing to a deeper understanding of ion channel involvement in the interplay of psoriasis and making a crucial advance toward more precise and personalized approaches for psoriasis treatment.

show abstract

Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder

Zhou,

Wu,

et al. 2024

Journal of Affective Disorders

View full text Add to dashboard Cite

TRPV4 Regulates the Development of Psoriasis by Controlling Adenosine Triphosphate Expression in Keratinocytes and the Neuroimmune System

Cited by 5 publications

References 50 publications

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Macrophage Functions in Psoriasis: Lessons from Mouse Models

Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis

Identification of CD19 as a shared biomarker via PPARγ/β-catenin/Wnt3a pathway linking psoriasis and major depressive disorder

Contact Info

Product

Resources

About