TRPV4 modulation affects mitochondrial parameters in adipocytes and its inhibition upregulates lipid accumulation
Shamit Kumar,
Tusar Kanta Acharya,
Satish Kumar
et al.
Abstract:Enhanced lipid-droplet formation by adipocytes is a complex process and relevant for obesity. Using knock-out animals, involvement of TRPV4, a thermosensitive ion channel in the obesity has been proposed. However, exact role/s of TRPV4 in adipogenesis and obesity remain unclear and contradictory. Here we used in vitro culture of 3T3L-1 preadipocytes and primary murine-mesenchymal stem cells as model systems, and a series of live-cell-imaging to analyse the direct involvement of TRPV4 exclusively at the adipocy… Show more
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