“…Numerous studies support an important role for endothelial TRPV4 channel-mediated arteriole dilation (Bagher et al, 2012;Marrelli, O'Neil, Brown, & Bryan Jr, 2007;Seki et al, 2017;Sonkusare et al, 2012;Zhang & Gutterman, 2011;Zhang, Papadopoulos, & Hamel, 2013;Zou, Leung, & Vanhoutte, 2015). However, in some vascular beds, TRPV4 channel activation can evoke constriction (Saifeddine et al, 2015;Soni, Peixoto-Neves, Matthews, & Adebiyi, 2017;Zhang et al, 2018). In the absence of NOmediated signaling, TRPV4 channel coupling with G-protein-couple receptor (GPCR) can amplify intracellular Ca 2+ events and generate vasoconstrictor prostanoids (Saifeddine et al, 2015;Zhang et al, 2018).…”