2017
DOI: 10.1152/ajprenal.00300.2017
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TRPV4 channels contribute to renal myogenic autoregulation in neonatal pigs

Abstract: Myogenic response, a phenomenon in which resistance size arteries and arterioles swiftly constrict or dilate in response to an acute elevation or reduction, respectively, in intravascular pressure is a key component of renal autoregulation mechanisms. Although it is well established that the renal system is functionally immature in neonates, mechanisms that regulate neonatal renal blood flow (RBF) remain poorly understood. In this study, we investigated the hypothesis that members of the transient receptor pot… Show more

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Cited by 22 publications
(25 citation statements)
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“…It is possible that mechanosensory tuning of outflow resistance under different pressure regimens, segmental flows of aqueous humor, and tensile strains on trabecular lamellae, involves concurrent and balanced activations of multiple mechanosensitive channels that include Piezo1, TRPV4 and TREK-1 (15,16,96). Also worth noting are the many parallels with cardiovascular and pulmonary systems in which mechanochannel activation by fluid flow profoundly regulates hydrostatic pressure gradients associated with tissue development, function and pathology (26,28,29,97,98). The delineation of the intertwined mechanisms that mediate the TM sensitivity to mechanical stress may help identify novel potential targets that can be exploited for precise IOP control and stabilization in glaucoma.…”
Section: Discussionmentioning
confidence: 99%
“…It is possible that mechanosensory tuning of outflow resistance under different pressure regimens, segmental flows of aqueous humor, and tensile strains on trabecular lamellae, involves concurrent and balanced activations of multiple mechanosensitive channels that include Piezo1, TRPV4 and TREK-1 (15,16,96). Also worth noting are the many parallels with cardiovascular and pulmonary systems in which mechanochannel activation by fluid flow profoundly regulates hydrostatic pressure gradients associated with tissue development, function and pathology (26,28,29,97,98). The delineation of the intertwined mechanisms that mediate the TM sensitivity to mechanical stress may help identify novel potential targets that can be exploited for precise IOP control and stabilization in glaucoma.…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, TRPV4 contributes to 5-hydroxytryptamine (5-HT)-mediated pulmonary vasoconstriction in chronic hypoxic pulmonary hypertension ( Xia et al, 2013 ). A recent study find that the inhibition of TRPV4 reverses steady-state myogenic tone and inhibits the pressure-evoked membrane depolarization, [Ca 2+ ] i increase and constriction in neonatal pig pre-glomerular distal interlobular arteries ( Soni et al, 2017 ). In addition, the blockade of TRPV4 channels attenuates angiotensin II (Ang II)-induced Ca 2+ entry and constriction in the pre-glomerular microvessels of neonatal pigs ( Soni et al, 2019 ).…”
Section: Transient Receptor Potential Vanilloid 4 and Vasoconstrictionmentioning
confidence: 99%
“…Numerous studies support an important role for endothelial TRPV4 channel-mediated arteriole dilation (Bagher et al, 2012;Marrelli, O'Neil, Brown, & Bryan Jr, 2007;Seki et al, 2017;Sonkusare et al, 2012;Zhang & Gutterman, 2011;Zhang, Papadopoulos, & Hamel, 2013;Zou, Leung, & Vanhoutte, 2015). However, in some vascular beds, TRPV4 channel activation can evoke constriction (Saifeddine et al, 2015;Soni, Peixoto-Neves, Matthews, & Adebiyi, 2017;Zhang et al, 2018). In the absence of NOmediated signaling, TRPV4 channel coupling with G-protein-couple receptor (GPCR) can amplify intracellular Ca 2+ events and generate vasoconstrictor prostanoids (Saifeddine et al, 2015;Zhang et al, 2018).…”
mentioning
confidence: 99%