TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence

Um, Ji Young; Kim, Han Bi; Kim, Jin Cheol; Park, Jin Seo; Lee, So Yeon; Chung, Bo Young; Park, Chun Wook; Kim, Hye One

doi:10.3390/ijms232314962

Cited by 11 publications

(11 citation statements)

References 71 publications

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“…TRPV3, abundantly found in epithelial cells, probably is the most essential TRPV channel to skin physiology and pathophysiology [ 26 ] and participates in various processes, including skin barrier formation [ 4 ], hair cycle regulation [ 6 ], and wound healing [ 5 ]. The level of TRPV3 mRNA and/or protein in skin cells was reported to be altered in several conditions, such as dermatitis [ 16 , 30 , 31 ], suggesting its potential role in the development of skin conditions [ 32 ]. Moreover, excessive TRPV3 activity was shown to be associated with inflammation and itches in Olmsted syndrome [ 10 , 11 , 16 ].…”

Section: Discussionmentioning

confidence: 99%

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

Dang,

Kim,

Kim

et al. 2023

IJMS

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The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated with various skin-related disorders. Since TRPV3 is involved in the development of skin inflammation, inhibiting TRPV3 could be a potential treatment strategy. Alpha-mangostin isolated from Garcinia mangostana L. extract exhibits diverse positive effects on skin health; however, the underlying mechanisms remain obscure. This study investigated the TRPV3-inhibitory properties of alpha-mangostin on TRPV3 hyperactive mutants associated with Olmsted syndrome and its impact on TRPV3-induced cytokine secretion and cell death. Our findings demonstrate that alpha-mangostin effectively inhibits TRPV3, with an IC50 of 0.077 ± 0.013 μM, showing inhibitory effects on both wild-type and mutant TRPV3. TRPV3 inhibition with alpha-mangostin decreased calcium influx and cytokine release, protecting cells from TRPV3-induced death. These results indicate that alpha-mangostin reduced inflammation in TRPV3-activated skin keratinocytes, suggesting that alpha-mangostin could be potentially used for improving inflammatory skin conditions such as dermatitis.

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Section: Discussionmentioning

confidence: 99%

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

Dang,

Kim,

Kim

et al. 2023

IJMS

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“…Recent studies have documented a significant increase in TRPV3 channel expression in severe scalp psoriatic lesions characterized by intense itching [ 13 , 65 ]. Importantly, gain-of-function mutations in TRPV3, identified in both mice and humans, are characterized by severe itching, hyperkeratosis, and elevated total IgE levels [ 29 , 66 ].…”

Section: Ion Channels In Keratinocytesmentioning

confidence: 99%

Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis

Kim,

Choi,

Jeon

et al. 2024

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of skin cells in the epidermis, driven by an overactive immune system. Consequently, a complex interplay among epidermal cells, immune cells, and sensory neurons contributes to the development and progression of psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP channels, Ca2+ release-activated channels, chloride channels, and potassium channels, each serve specific functions to maintain the homeostasis of the skin. The dysregulation of ion channels plays a major role in the pathophysiology of psoriasis, affecting various aspects of epidermal cells, immune responses, and sensory neuron signaling. Impaired function of ion channels can lead to altered calcium signaling, inflammation, proliferation, and sensory signaling, all of which are central features of psoriasis. This overview summarizes the pathophysiological roles of ion channels in epidermal cells, immune cells, and sensory neurons during early and late psoriatic processes, thereby contributing to a deeper understanding of ion channel involvement in the interplay of psoriasis and making a crucial advance toward more precise and personalized approaches for psoriasis treatment.

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“…An increasing number of studies have shown that keratinocyte-expressed TRPV3 is involved in chronic pruritus and itch transmission [76]. Han et al [77] reported that citrusinine-II, a plant-derived natural acridone alkaloid from A. monophylla, is a potent and selective antagonist of TRPV3 that has a strong antipruritic effect in both in vivo and in vitro experiments.…”

Section: Trp Cation Channel Subfamily V (Vanilloid) Member 2 (Trpv2)mentioning

confidence: 99%

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

Tsagareli,

Follansbee,

Iodi Carstens

et al. 2023

Pharmaceuticals

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Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch-evoking ligands. Also expressed in pruriceptors are several types of Transient Receptor Potential (TRP) channels. TRP channels are a diverse class of cation channels that are responsive to various somatosensory stimuli like touch, pain, itch, and temperature. In pruriceptors, TRP channels can be activated through intracellular signaling cascades initiated by pruritogen receptors and underly neuronal activation. In this review, we discuss the role of TRP channels TRPA1, TRPV1, TRPV2, TRPV3, TRPV4, TRPM8, and TRPC3/4 in acute and chronic pruritus. Since these channels often mediate itch in association with pruritogen receptors, we also discuss Mas-related G-protein-coupled receptors (Mrgprs) and protease-activated receptors (PARs). Additionally, we cover the exciting therapeutic targets amongst the TRP family, as well as Mrgprs and PARs for the treatment of pruritus.

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TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence

Cited by 11 publications

References 71 publications

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

Pathophysiological Roles of Ion Channels in Epidermal Cells, Immune Cells, and Sensory Neurons in Psoriasis

Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch

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