TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications

NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice

“…It has been well-established that AW 453 induces potent depressive behaviors in both animals454 and humans(Barr and Markou, 2005) Martins et al, 2014;. Aguiar et al, 2014).470 These channels are widely distributed in brain structures 471 such as limbic system and cortical areas which are critical 472 regions of the brain involved in cognitive and behavioral 473 processes(Cristino et al, 2006;Edwards, 2014). Our 474 results revealed that administration of capsaicin and cap-475 sazepine dose-dependently decreased the immobility 476 time in control mice.…”

“…to impaired activity of dopaminergic system in mesocorti-492 colimbic pathway (Koob, 1992;George et al, 2012;Der-493 Avakian and Markou, 2012). It has been shown that 494 TRPV1 channels are expressed in dopaminergic neurons 495 in the several regions of the brain including hippocampus 496 and cortical areas (Cristino et al, 2006;Edwards, 2014). 497 Activation of TRPV1 channels is known to induce depolar-498 ization in the neurons through enhancing the calcium 499 influx (Madasu et al, 2015).…”

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

“…Neurobehavioral studies indicate that TRPV1 is critically involved in neurological and psychiatric disorders such as epilepsy, anxiety and depression as well as drug-addiction disorders15. Concerning TRPV1 expression, although still controversial16, much evidence indicates that TRPV1 is expressed in neuronal and glial cells of various brain regions, although at lower levels than in peripheral structures and spinal cord17181920.…”

Spontaneous l-glutamate release enhancement in rat substantia gelatinosa neurons by (−)-carvone and (+)-carvone which activate different types of TRP channel

“…Since TRPV1 and TRPA1 channels are expressed in not only primary-afferent neurons but also the central nervous system (see Refs. [29,30] for review), at least a part of the pharmacological actions of carvone on the nervous system may be mediated by the activation of the channels. Such a difference in TRP activation between (À)-carvone and (þ)-carvone may serve to know the properties of the TRP channels.…”