TRPV1 in Pain and Itch

Li, Fengxian; Wang, Fang

doi:10.1007/978-981-16-4254-8_12

Cited by 22 publications

(16 citation statements)

References 152 publications

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“…The CeA acts as an emotional integration centre and participates in the regulation of pain and anxiety. TRPV1 plays a role in the formation of pain sensitisation and neuropathic pain by interacting with in ammatory mediators and affecting the excitability of nerve bres and neurons [31]. In this study, TRPV1 expression in the CeA of rats with orthodontic tooth movement was analysed.…”

Section: Discussionmentioning

confidence: 99%

Increased expression of TRPV1 in the central nucleus of the amygdala is involved in orthodontic pain during experimental tooth movement in rats

Wang

Fang

et al. 2023

Preprint

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Pain is one of the most common adverse reactions during orthodontic treatment, which troubles patients a lot. Transient receptor potential vanilloid 1 (TRPV1) plays a crucial role in pain transmission and is expressed in the peripheral nervous system, but there is a paucity of literature on the roles of TRPV1 in the central nervous system. The central amygdala (CeA) integrates multiple sensory signals including nociceptive sensory information. However, how the involvement of TRPV1 in the CeA in orthodontic pain has not been investigated. To explore this, we constructed an experimental tooth movement (ETM) model using precision springs and evaluated pain behaviour based on face-grooming and the rat grimace scale (RGS). TRPV1 expression in the CeA was evaluated using immunofluorescence and western blotting. Face-grooming and RGS score peaked on day 1 then decreased gradually to baseline levels on day 7. Immunofluorescence and western blotting analysis revealed that TRPV1 expression in the CeA increased after ETM. Furthermore, changes in TRPV1 expression in the CeA were positively associated with RGS behaviour. Our findings suggest that TRPV1 in the CeA is modulated by ETM and is involved in tooth-movement pain, providing a new understanding of central regulation on orthodontic pain.

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Section: Discussionmentioning

confidence: 99%

Increased expression of TRPV1 in the central nucleus of the amygdala is involved in orthodontic pain during experimental tooth movement in rats

Wang

Fang

et al. 2023

Preprint

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“…Aδ fibers receive signals from bladder contraction and expansion, while C fibers respond to thermal changes and chemical and pain stimuli [ 165 ]. Molecular sensors on the afferent nerve, including transient receptor potential A1 (TRPA1) [ 166 ], TRPV1 [ 167 ], and transient receptor potential cation channel subfamily M member-3 (TRPM3) channel [ 168 ], have been identified as mediators for the conveyance of pain signals. In addition, the TRPM3 channel also acts as a thermal sensor, causing thermal hypersensitivity in humans [ 169 ].…”

Section: The Fundamental Research Of Ic/bpsmentioning

confidence: 99%

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome

2022

IJMS

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Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating disease that induces mental stress, lower urinary symptoms, and pelvic pain, therefore resulting in a decline in quality of life. The present diagnoses and treatments still lead to unsatisfactory outcomes, and novel diagnostic and therapeutic modalities are needed. Although our understanding of the etiology and pathophysiology of IC/BPS is growing, the altered permeability of the impaired urothelium, the sensitized nerves on the bladder wall, and the chronic or intermittent sensory pain with inaccurate location, as well as pathologic angiogenesis, fibrosis, and Hunner lesions, all act as barriers to better diagnoses and treatments. This study aimed to summarize the comprehensive information on IC/BPS research, thereby promoting the progress of IC/BPS in the aspects of diagnosis, treatment, and prognosis. According to diverse international guidelines, the etiology of IC/BPS is associated with multiple factors, while the presence of Hunner lesions could largely distinguish the pathology, diagnosis, and treatment of non-Hunner lesions in IC/BPS patients. On the basis of the diagnosis of exclusion, the diverse present diagnostic and therapeutic procedures are undergoing a transition from a single approach to multimodal strategies targeting different potential phenotypes recommended by different guidelines. Investigations into the mechanisms involved in urinary symptoms, pain sensation, and bladder fibrosis indicate the pathophysiology of IC/BPS for further potential strategies, both in diagnosis and treatment. An overview of IC/BPS in terms of epidemiology, etiology, pathology, diagnosis, treatment, and fundamental research is provided with the latest evidence. On the basis of shared decision-making, a multimodal strategy of diagnosis and treatment targeting potential phenotypes for individual patients with IC/BPS would be of great benefit for the entire process of management. The complexity and emerging evidence on IC/BPS elicit more relevant studies and research and could optimize the management of IC/BPS patients.

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“…Twenty years after its cloning, TRPV1 has become the first family member with a postulated and subsequently verified link to chronic pain and pruritus with increasing evidence that considers this receptor as a hub for algesic and pruritogenic agents (Li and Wang, 2021). This evidence is further supported by the analgesic, anti-inflammatory and anti-pruritogenic activities of capsaicin (Basith et al, 2016).…”

Section: Introductionmentioning

confidence: 96%

“…Intense research in the past years has started to unveil the cellular and molecular mechanisms involved in the pathogenesis of chronic pain and pruritus, and to delineate the signaling pathways involved in the maintenance of nociceptor sensitization upon the triggering condition has resolved. Cumulative evidence signals to the transient receptor potential (TRP) channel superfamily as a central player in somatosensory signaling, particularly TRPV1 (Li and Wang, 2021). The TRP superfamily is composed of 28 members divided into six subfamilies, classified as canonical (TRPC), vanilloid (TRPV), ankyrin (TRPA), melastatin (TRPM), polycystin (TRPP), and mucolipin (TRPML) (Venkatachalam et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy

Fernández-Carvajal

Fernández‐Ballester

Ferrer‐Montiel

2022

Front. Mol. Neurosci.

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Chronic pain and pruritus are highly disabling pathologies that still lack appropriate therapeutic intervention. At cellular level the transduction and transmission of pain and pruritogenic signals are closely intertwined, negatively modulating each other. The molecular and cellular pathways involved are multifactorial and complex, including peripheral and central components. Peripherally, pain and itch are produced by subpopulations of specialized nociceptors that recognize and transduce algesic and pruritogenic signals. Although still under intense investigation, cumulative evidence is pointing to the thermosensory channel TRPV1 as a hub for a large number of pro-algesic and itchy agents. TRPV1 appears metabolically coupled to most neural receptors that recognize algesic and pruritic molecules. Thus, targeting TRPV1 function appears as a valuable and reasonable therapeutic strategy. In support of this tenet, capsaicin, a desensitizing TRPV1 agonist, has been shown to exhibit clinically relevant analgesic, anti-inflammatory, and anti-pruritic activities. However, potent TRPV1 antagonists have been questioned due to an hyperthermic secondary effect that prevented their clinical development. Thus, softer strategies directed to modulate peripheral TRPV1 function appear warranted to alleviate chronic pain and itch. In this regard, soft, deactivatable TRPV1 antagonists for topical or local application appear as an innovative approach for improving the distressing painful and itchy symptoms of patients suffering chronic pain or pruritus. Here, we review the data on these compounds and propose that this strategy could be used to target other peripheral therapeutic targets.

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TRPV1 in Pain and Itch

Cited by 22 publications

References 152 publications

Increased expression of TRPV1 in the central nucleus of the amygdala is involved in orthodontic pain during experimental tooth movement in rats

Increased expression of TRPV1 in the central nucleus of the amygdala is involved in orthodontic pain during experimental tooth movement in rats

Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome

TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy

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