TRPV1 Genetics

Dorfman, Ruslan; Tsui, Hubert; Salter, Michael W.; Hm, Dosch

doi:10.1002/9780470588284.ch4

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…A model is provided to explain how TRPV1 signaling in the PANEM complex may be sustained at body temperature. We conducted parallel studies of patients from the Canadian Collaborative Project on Genetic Susceptibility to Multiple Sclerosis (CCPGSMS), a large and lengthy population-based study (26)(27)(28), focusing on the extremely polymorphic TRPV1 locus (29). We found a significant missense single nucleotide polymorphism (SNP) selection bias in patients with a very progressive disease course, indicating that the unexpected core role of TRPV1 may extend to patients with MS.…”

Section: Trpv1 Gates Tissue Access and Sustains Pathogenicity In Automentioning

confidence: 99%

“…We chose a genomic approach, based on the extreme allelic polymorphism of the human TRPV1 locus (29), and analyzed a cohort of MS patients from the CCPGSMS trial (28). Measuring allelic variation in TRPV1 and Tac1 genes, single nucleotide polymorphisms (SNPs) were compared in genomic DNA from MS cases at opposite extremes of long-term clinical outcomes, as assessed by the EDSS.…”

Section: A Role For Trpv1 But Not Tac1 In Eae and Msmentioning

confidence: 99%

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TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

Paltser

Liu

Yantha

et al. 2013

Mol Med

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Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) expressed in a major sensory neuron subset, controls severity and progression of experimental autoimmune encephalomyelitis (EAE) in mice and likely in primary progressive MS. TRPV1 -/-B6 congenics are protected from EAE. Increased survival reflects reduced central nervous systems (CNS) infiltration, despite indistinguishable T cell autoreactivity and pathogenicity in the periphery of TRPV1-sufficient and -deficient mice. The TRPV1 + neurovascular complex defining the blood-CNS barriers promoted invasion of pathogenic lymphocytes without the contribution of TRPV1-dependent neuropeptides such as substance P . In MS patients, we found a selective risk-association of the missense rs877610 TRPV1 single nucleotide polymorphism (SNP) in primary progressive disease. Our findings indicate that TRPV1 is a critical disease modifier in EAE, and we identify a predictor of severe disease course and a novel target for MS therapy.

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Section: Trpv1 Gates Tissue Access and Sustains Pathogenicity In Automentioning

confidence: 99%

Section: A Role For Trpv1 But Not Tac1 In Eae and Msmentioning

confidence: 99%

TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

Paltser

Liu

Yantha

et al. 2013

Mol Med

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“…Transient receptor potential vanilloid-1 (TRPV1) is the founding member of a growing family of complex neuronal sensors [5] that unexpectedly, play an important role in the non-obese diabetic (NOD) rodent model of T1D [6]. Indeed, TRPV1 maps to the idd4 locus with TRPV1 NOD , a unique hypofunctional mutant resulting from two amino acid substitutions that generate an overall hyposecretory phenotype [3].…”

Section: Sensory Neurons and Type 1 Diabetesmentioning

confidence: 99%

‘Sensing’ the link between type 1 and type 2 diabetes

Tsui

Paltser

Chan

et al. 2011

Diabetes Metabolism Res

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Obesity-associated insulin resistance is a core element of metabolic syndrome and type 2 diabetes (T2D). Notably, insulin resistance is also a feature of type 1 diabetes (T1D), where findings in the non-obese diabetic mouse model have implicated transient receptor potential vanilloid-1 (TRPV1+) sensory neurons in local islet inflammation and glucose metabolism. Here, we briefly review the role of TRPV1 in non-obese diabetic (NOD) T1D pathogenesis, highlighting commonalities that suggest TRPV1 may contribute to obesity and T2D as well. With the recently discovered importance of adipose infiltrating lymphocytes in the metabolic disturbances of obesity and T2D, sensory innervation of fat may thus play an analogous role to sensory neurons in the islet--modulating neuroendocrine homeostasis and inflammation. In such a scenario, TRPV1+ sensory nerves would provide the pathoaetiological link connecting the shared metabolic and immunologic features of type 1 diabetes and T2D.

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Capsaicin Receptor TRPV1: Biophysics, Physiology, and Pharmacology

Li,

Zheng

2024

Capsaicinoids

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TRPV1 Genetics

Cited by 3 publications

References 37 publications

TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

TRPV1 Gates Tissue Access and Sustains Pathogenicity in Autoimmune Encephalitis

‘Sensing’ the link between type 1 and type 2 diabetes

Capsaicin Receptor TRPV1: Biophysics, Physiology, and Pharmacology

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