TRPV1 Channels Regulate Cortical Excitability in Humans

Mori, Francesco; Ribolsi, Michele; Kusayanagi, Hajime; Monteleone, Fabrizia; Mantovani, Vilma; Buttari, Fabio; Marasco, Elena; Bernardi, Giorgio; Maccarrone, Mauro; Centonze, Diego

doi:10.1523/jneurosci.2531-11.2012

Cited by 76 publications

(59 citation statements)

References 63 publications

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“…TRPV 1 R channels are also expressed in the brain beyond the central endings of the sensory pathways, and are believed to participate in the fine-tuning of several types of synapses (Mezey et al, 2000;Roberts et al, 2004;Grueter et al, 2010;Matta and Ahern, 2011;Mori et al, 2012). Apart from the (anti)nociceptive pathways, functional experiments pointed out presynaptic location for the TRPV 1 R in the forebrain (see Table 1 as well as Matta and Ahern, 2011), while other studies also found it post-synaptically (Tóth et al, 2005;Cristino et al, 2006;Marsch et al, 2007;Li et al, 2008;Maccarrone et al, 2008;Mulder et al, 2011;Grueter et al, 2010;Zschenderlein et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

Köles

Garção

Zádori

et al. 2013

Brain Research Bulletin

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Neocortical and striatal TRPV1 (vanilloid or capsaicin) receptors (TRPV1Rs) are excitatory ligand-gated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV1Rs in glutamatergic, serotonergic or dopaminergic terminals of the rodent forebrain remains little understood. With the help of patch-clamp electrophysiology and neurochemical approaches, we mapped the age-dependence of presynaptic TRPV1R function, and furthermore, we aimed at exploring whether the presence of CB1 cannabinoid receptors (CB1Rs) influences the function of the TRPV1Rs, as both receptor types share endogenous ligands. We found that the major factor which affects presynaptic TRPV1R function is age: by post-natal day 13, the amplitude of capsaicin-induced release of dopamine and glutamate is halved in the rat striatum, and two weeks later, capsaicin already loses its effect. However, TRPV1R receptor function is not enhanced by chemical or genetic ablation of the CB1Rs in dopaminergic, glutamatergic and serotonergic terminals of the mouse brain. Altogether, our data indicate a possible neurodevelopmental role for presynaptic TRPV1Rs in the rodent brain, but we found no cross-talk between TRPV1Rs and CB1Rs in the same nerve terminal. AbstractNeocortical and striatal TRPV 1 (vanilloid or capsaicin) receptors (TRPV 1 Rs) are excitatory ligandgated ion channels, and are implicated in psychiatric disorders. However, the purported presynaptic neuromodulator role of TRPV 1 Rs in glutamatergic, serotonergic or dopaminergic terminals of the rodent forebrain remains little understood. With the help of patch-clamp electrophysiology and neurochemical approaches, we mapped the age-dependence of presynaptic TRPV 1 R function, and furthermore, we aimed at exploring whether the presence of CB 1 cannabinoid receptors (CB 1 Rs) influences the function of the TRPV 1 Rs, as both receptor types share endogenous ligands.We found that the major factor which affects presynaptic TRPV 1 R function is age: by post-natal day 13, the amplitude of capsaicin-induced release of dopamine and glutamate is halved in the rat striatum, and two weeks later, capsaicin already loses its effect. However, TRPV 1 R receptor function is not enhanced by chemical or genetic ablation of the CB 1 Rs in dopaminergic, glutamatergic and serotonergic terminals of the mouse brain.Altogether, our data indicate a possible neurodevelopmental role for presynaptic TRPV 1 Rs in the rodent brain, but we found no cross-talk between TRPV 1 Rs and CB 1 Rs in the same nerve terminal.

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Section: Introductionmentioning

confidence: 99%

Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

Köles

Garção

Zádori

et al. 2013

Brain Research Bulletin

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“…A recent report suggests that TRPV1 regulates cortical excitability [54]. This study describes a SNP allele in the TRPV1 channel which is associated with enhanced synaptic transmission in the cerebral cortex.…”

Section: Trp Channels and Migraine Triggersmentioning

confidence: 81%

“…Currently, TRPV1 is thought to be more widely distributed than originally thought and it has been detected in periaqueductal grey, hypothalamus, thalamus, amygdala, cortex, olfactory bulb, trigeminal nucleus caudalis and a number of other regions of the brain in humans, rats and mice [33,34,47,52,53] but see [49]. Several reports have also suggested that TRPV1 is functional in the CNS in several areas including cerebral cortex [54], dentate gyrus [55], and hippocampus [56,57].…”

Section: Trpv1 Localizationmentioning

confidence: 99%

The Role of TRP Channels in Migraine

Oxford¹,

Hurley²

2013

TOPAINJ

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TRP channels are members of a large family of non-selective cation channels. The family which numbers over 30 is classified into 6 groups based on amino acid sequence homology. TRP channels are distributed in many peripheral tissues as well as central and peripheral nervous system. These channels are important in sensing a wide range of chemical and physical stimuli. Several TRP channels, including TRPV1 and TRPA1 are important in pain transduction pathways. This review will focus on the function of TRP channels in the trigeminovascular system and other anatomical regions which are relevant to migraine. We will discuss the possible role of TRP channels in migraine, including the potential role of TRPV1 in the hypersensitivity and allodynia frequently observed in migraine patients. We will review the status of TRP channel drugs in migraine therapeutics. We will also discuss the possible roles of TRP channels in triggering migraine attacks, a process which is not well-understood.

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“…28 Additionally, Mori and colleagues have shown that TRPV1 plays a role in cortical excitability by regulating glutamatergic synaptic transmission. 29 In a recent study, Eslamizade et al, 2015 have suggested that Ab could influence excitability of these neurons through modification of the activity of TRPV1. 30 They conclude that dysregulation of PIP2 metabolism by Ab could be partly responsible for neuronal death through changes in TRPV1 function.…”

Section: Trpv Subfamilymentioning

confidence: 99%

“…TRPV4 is a channel activated by temperatures that range from [27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] C, by changes in osmotic pressure and by molecules of a lipid nature which are downstream of the activity of PLC, 39 among others. In this case, binding of PIP2 to the N-terminus of TRPV4 was shown to be important for activation of the channel by heat and hypotonic stimuli.…”

mentioning

confidence: 99%

Regulation of thermoTRPs by lipids

2016

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The family of Transient Receptor Potential (TRP) ion channels is constituted by 7 subfamilies among which are those that respond to temperature, the thermoTRPs. These channels are versatile molecules of a polymodal nature that have been shown to be modulated in various fashions by molecules of a lipidic nature. Some of these molecules interact directly with the channels on specific regions of their structures and some of these promote changes in membrane fluidity or modify their gating properties in response to their agonists. Here, we have discussed how some of these lipids regulate the activity of thermoTRPs and included some of the available evidence for the molecular mechanisms underlying their effects on these channels.

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TRPV1 Channels Regulate Cortical Excitability in Humans

Cited by 76 publications

References 63 publications

Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

Presynaptic TRPV1 vanilloid receptor function is age- but not CB1 cannabinoid receptor-dependent in the rodent forebrain

The Role of TRP Channels in Migraine

Regulation of thermoTRPs by lipids

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